临床与实验病理学杂志2017，Vol.33Issue(1)：22-26,5.DOI:10.13315/j.cnki.cjcep.2017.01.006
卵巢浆液性腺癌中SP1、KLF4和p21表达及其预后意义
Expression and prognostic significance of SP1, KLF4 and p21 in ovarian serous carcinoma
摘要
Abstract
Purpose To explore the difference of expression and prognostic significance of SP1,KLF4 and p21 in low grade ovarian serous carcinoma (LGSC) and high grade ovarian serous carcinoma (HGSC).Methods The expression of SP1,KLF4 and p21 protein was examined with immunohistochemistry EliVision method in cases with LGSC and HGSC.Kaplan-Meier analysis and Cox multivariate survival analysis were used to assess the impact of SP1,KLF4 and p21 expression on prognosis of LGSC and HGSC.Results SP1,KLF4 and p21 expression were detected respectively in 74.5％,17.0％ and 11.7％ HG-SC cases,and in 65.2％,34.8％ and 26.1％ LGSC cases.Compared to control group,the expression level of SP1 was significantly higher (P ＜ 0.05),but the expression level of KLF4 and p21 were significantly lower (P ＜0.05).There was no significant difference of SP1,KLF4 and p21 expression between HGSC and LGSC (P ＞ 0.05).The expression of SP1,KLF4 and p21 were associated with FIGO stage,meanwhile SP1 associated with residual tumor size in HGSC (P ＜ 0.05).There was a significant negative correlation between SP1 and KLF4,p21 proteins in HGSC (P ＜ 0.05).Kaplan-Meier analysis revealed that there were significantly poor overall survival (OS) of 5 years for patients with HGSC displaying high expression of SP1,or low expression of KLF4 and p21 (P ＜0.05),but no significantly improved OS for patients with LGSC (P ＞ 0.05).Cox analysis showed that SP1 overexpression is an independent prognosis factor for HGSC.Conclusion Overexpression of SP1 and low expresion of KLF4 and p21 contribute to carcinogenesis of HGSC and LGSC.They are associated with a poor prognosis of HGSC,but not LGSC,meanwhile SP1 is an independant prognosis factor for HGSC.关键词
卵巢肿瘤/浆液性腺癌/SP1/KLF4/p21/预后Key words
ovary neoplasm/serous adenocarcinoma/SP1/KLF4/p21/prognosis分类
医药卫生引用本文复制引用
张军,汪瑞雪,樊晓妹,娄蕾,刘围娜,赵喜娃,李月红..卵巢浆液性腺癌中SP1、KLF4和p21表达及其预后意义[J].临床与实验病理学杂志,2017,33(1):22-26,5.基金项目
河北省科技支撑计划(16277794D) （16277794D）
