临床与实验病理学杂志2017，Vol.33Issue(1)：31-34,4.DOI:10.13315/j.cnki.cjcep.2017.01.008
子宫颈腺样基底细胞癌4例临床病理观察
Clinicopathologic study of cervical adenoid basal carcinoma
摘要
Abstract
Purpose To study the clinicalpathologic features,diagnosis,differential diagnosis and prognosis of cervical adenoid basal carcinoma (ABC) for improving further recognition and avoiding the likelihood of unnecessarily aggressive treatment to this disease.Methods Clinical presentations and pathological features of 4 cases of cervical ABC were analyzed by hematoxylin and eosin staining,immunohistochemical EnVision staining and in situ hybridization technology.The relevant literatures were reviewed.Results The age of 4 cases with cervical ABC ranged from 53 to 67 years (mean:61.5 years).All of the 4 patients underwent hysterectomy with bilateral salpingo-oophorectomy.Microscopically,the tumors were composed of small,well-differentiated and uniform basaloid cells and the tumor cells formed rounded nests or cords.The tumor cells arranged in palisading at the periphery of the nests.Some of the nests had central cystic spaces and there may also be focal glandular or squamous differentiation in the centre of the nests.Cervical intraepithelial neoplasia (CIN) lesions were observed in all 4 cases.Immunohistochemically,all the tumor cells were negative for CK7,ER,CEA,CD117 and S-100,while CK5/6,CK8/18,CK19,p16,p53,BCL-2 and p63 were positive.HPV 16/18 DNA were positive by in situ hybridization.The patients remained alive without recurrence and metastasis after follow-up 19 to 62 months.Conclusion ABC of the uterine cervix is a rare neoplasm with excellent prognosis.Differentiation of ABC from adenoid cystic carcinoma,basaloid squamous carcinoma,neuroendocrine carcinoma and adenosquamous carcinoma is important due to their different prognosis.Treatment is predominantly hysterectomy or laser electrocantery excision procedure (Leep).Radiotherapy or chemotherapy is not recommeded.关键词
子宫颈肿瘤/腺样基底细胞癌/鉴别诊断/预后Key words
cervical neoplasm/adenoid basal carcinoma/differential diagnosis/prognosis分类
医药卫生引用本文复制引用
肖桂香,刘翠,黄邦杏,陈烁,吴钧华,聂秀..子宫颈腺样基底细胞癌4例临床病理观察[J].临床与实验病理学杂志,2017,33(1):31-34,4.基金项目
湖北省自然基金(2015CFB654) （2015CFB654）
