临床与实验病理学杂志2017，Vol.33Issue(1)：50-54,5.DOI:10.13315/j.cnki.cjcep.2017.01.013
乳腺癌中BCL-6和ZEB2的表达及其意义
Expression and significance of BCL-6 and ZEB2 in breast cancer
摘要
Abstract
Purpose To explore the biological significance of BCL-6 and ZEB2 in invasion,metastasis and prognosis of breast cancer.Methods The expressions of BCL-6,ZEB2 protein and mRNA were detected respectively in 228 cases of breast cancer and 80 cases of breast benign lesions by immunohistochemical SP two-step staining and situ hybridization.Result The expression levels of BCL-6,ZEB2 protein and mRNA in breast cancer tissues were significantly higher than in breast benign lesions (P ＜ 0.05).The expressions of BCL-6 was positively correlated with tumor size,lymphatic metastasis,histological grade,TNM staging and HER-2 expression (P ＜ 0.05).The expressions of ZEB2 was positively correlated with tumor size,lymphatic metastasis,TNM staging and HER-2 expression (P ＜ 0.05).The overall survival and relapse-free survival of BCL-6 and ZEB2 positive expression were significantly less than the negative expression (P ＜ 0.01).Conclusion The BCL-6 and ZEB2 are closely correlated with the evolution process of breast cancer,which may become important means for monitoring and warning the metastasis,invasion,and prognosis of breast cancer.关键词
乳腺肿瘤/BCL-6/ZEB2/免疫组织化学/原位杂交Key words
breast neoplasm/BCL-6/ZEB2/immunohistochemisty/situ hybridization分类
医药卫生引用本文复制引用
郑丽,赵敏,昂琳,黄金,王瑾,邹强,吴正升..乳腺癌中BCL-6和ZEB2的表达及其意义[J].临床与实验病理学杂志,2017,33(1):50-54,5.基金项目
合肥市自主创新政策“借转补”项目[合科(2014)71号] （2014）
