河南科技大学学报（医学版）2017，Vol.35Issue(1)：1-3,3.DOI:10.15926/j.cnki.issn1672-688x.2017.01.001
槐定碱通过Caspase-3介导的人胰腺癌细胞株capan-1凋亡机制研究
Effect of Sophoridine on Apoptosis of Human Pancreatic Cancer Cell Line Capan-1 by Caspase-3 Signaling Pathway
摘要
Abstract
Objective To investigate the effects of sophoridine on apoptosis of human pancreatic cancer cell line capan-1 by Caspase-3 signaling pathway.Methods CCK-8 was used to detect the effect of sophoridine on the viability of capan-1 cells.Apoptosis was observed by Hoechest 33342 staining.The expression of Caspase-3 was detected by spectrophotometry.Results Compared with the control group, sophoridine could significantly inhibit the growth of capan-1 cells(P<0.05), promote cell apoptosis(P<0.05), up-regulate the expression of Caspase-3(P<0.05).Conclusion Sophoridine could inhibit the proliferation of capan-1 cells and promote cell apoptosis, which was related to the up-regulation of Caspase-3.关键词
胰腺癌/capan-1/槐定碱/Caspase-3Key words
pancreatic cancer/capan-1/sophoridine/Caspase-3分类
医药卫生引用本文复制引用
任丽平,李先佳,金少举..槐定碱通过Caspase-3介导的人胰腺癌细胞株capan-1凋亡机制研究[J].河南科技大学学报（医学版）,2017,35(1):1-3,3.基金项目
1.河南省科技攻关计划(社会发展领域)(162102310596)2.河南省高等学校重点科研资助项目(16B310004)3.漯河医学高等专科学校2016年度校级研究资助计划项目(2016-S-LMC-13) （社会发展领域）
