河南科技大学学报（医学版）2017，Vol.35Issue(1)：4-6,10,4.DOI:10.15926/j.cnki.issn1672-688x.2017.01.02
壁虎醇提物急性毒性研究
Acute Toxicity of Alcohol Extract from Gecko with Mice
摘要
Abstract
Objective To investigate the acute toxicity of alcohol extract from gecko with mice.Methods The median lethal dose (LD50) was investigated by using acute toxicity test.A small amount of mice with large dose range administration of alcohol extract from gecko were used to find out the lethal range in preliminary experiment, and between total and zero lethal dose experimental male mice were divided into five groups(10 male mice per group) and the dose ratio of each group was calculated.The results were calculated with improved Kou′s method.Results No death appeared in mice with intragastric administration, and reduction of activities and languishment were found during one hour after administration.The maximum tolerated dose (MTD) of was 48.0 g·kg-1.LD50 by intraperitoneal injection was 6.475 g·kg-1 in mice and 95% confidence limit was 6.862~6.088 g·kg-1.Conclusion This study suggested that alcohol extract of gecko was very small toxicity and relative safe in clinical application.关键词
壁虎醇提物/急性毒性试验/半数致死量/最大耐受量Key words
gecko alcohol extract/acute toxicity test/median lethal dose/maximum tolerated dose分类
医药卫生引用本文复制引用
郭梦丽,王建刚,靳颖,段一梦..壁虎醇提物急性毒性研究[J].河南科技大学学报（医学版）,2017,35(1):4-6,10,4.基金项目
河南省科技重点攻关基金资助项目(102102310063) （102102310063）
