河南科技大学学报（医学版）2017，Vol.35Issue(1)：50-52,3.DOI:10.15926/j.cnki.issn1672-688x.2017.01.016
重组人促红细胞生成素对早产儿脑损伤预后的影响
Prognosis Value of Recombinant Human Erythropoietin on Premature Brain Injury
耿琳琳 1甘红红1
作者信息
- 1. 复旦大学附属中山医院青浦分院,上海 201700
- 折叠
摘要
Abstract
Objective To investigate the protective effect of recombinant human erythropoietin(rhEPO) as an angiogenesis-like factor for preterm infants with brain damage.Methods There were 60 cases of preterm infants admitted to the neonatal ward of our hospital from January 2012 to June 2014, and according to hospital successively order, the premature were randomly divided into preterm group and preterm+rhEPO group.There were 30 cases of term infants as control group admitted maternal infantile ward at the same time.Preterm+rhEPO group were given subcutaneous injection of rhEPO from the 7th days after admission and 2 400 IU·kg-1 per week(3 times divided) for 4 weeks.The changes of neurobehavioral development in children were observed by Children′s Developmental Center of China infant mental development test at 6 months, 12 months,18 months after gestational age corrected.Results The score of preterm + rhEPO group was better than that of preterm group, and the difference were statistically significant at 12 months,18 months after gestational age corrected compared with the preterm group (all P< 0.01).ConclusionrhEPO(2 400 IU·kg-1) may have protective effects on preterm brain injury.关键词
重组人促红细胞生成素/早产儿/脑损伤Key words
recombinant human erythropoietin/preterm infant/brain injuries分类
医药卫生引用本文复制引用
耿琳琳,甘红红..重组人促红细胞生成素对早产儿脑损伤预后的影响[J].河南科技大学学报（医学版）,2017,35(1):50-52,3.
