南京师大学报（自然科学版）2016，Vol.39Issue(4)：71-81,11.DOI:10.3969/j.issn.1001-4616.2016.04.013
基于PXRD、DSC和NIR技术的那格列奈多晶型的定量分析方法研究
A Comparative Study on Quantification of Binary Polymorphic Mixtures of Nateglinide by Using Powder X-Ray Diffraction,Differential Scanning Calorimetry and Near Infrared Spectroscopy
摘要
Abstract
The aim of this study is to evaluate the ability of powder X-ray diffraction (PXRD),differential scanning calorimetry(DSC) and near infrared (NIR)spectroscopy to quantify two polymorphic forms (B,H)of nateglinide in binary powder mixtures.For this purpose,univariate and multivariate method are developed.The results show that PXRD (with PLS regression)provides a reliable determination of nateglinide samples(predicted accuracy of 89.1％),which is the best choice for quantification of nateglinide polymorphic mixtures in practice,while NIR spectroscopy is the least accurate (predicted accuracy of 79.6％)mainly due to the effect of sample inhomogeneity.Though a good linear relation and a high predicted accuracy(93.4％)for DSC are successfully obtained,it could not be a practical way for low-content quantification in nateglinide polymorphic mixtures.关键词
那格列奈多晶型/定量分析/X-射线粉末衍射法/差示扫描量热法/近红外光谱法Key words
nateglinide polymorphs/quantification/powder X-ray diffraction/differential scanning calorimetry/near infrared spectroscopy分类
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邱晶波,谢梦雨,沈晓敏,周丹,朱慕荣,李钢..基于PXRD、DSC和NIR技术的那格列奈多晶型的定量分析方法研究[J].南京师大学报（自然科学版）,2016,39(4):71-81,11.基金项目
Supported by Jiangsu Large Scientific Instruments Shared Services Platform Foundation (BZ201403). （BZ201403）
