四川大学学报（自然科学版）2017，Vol.54Issue(1)：178-184,7.DOI:103969/j.issn.0490-6756.2017.01.030
新型2-甲基-3-呋喃甲酰胺类化合物的设计、合成及抑菌活性研究
Design, synthesis and antifungal activity of novel 2-methyl-3-furancarboxamide derivatives
摘要
Abstract
Based on the structure of the fungicide fenfuram for exploring high antifungal agents,twenty novel 2-methyl-3-furancarboxamide derivatives were designed,synthesized and characterized by1 H NMR.Then,their in vitro antifungal activities were evaluated against five normal phytopathogenic fungi (Rhizoctonia solani,Sclerotinia sclerotiorum,Ph ytophthora in f estans,P ythium a phanidermatum and Physalospora piricola) by mycelial growth inhibition method.In conclusion,compounds 1e,1f,2a,2b and 2f exhibited stronger antifungal effects on R.solani with inhibition rates of 88.6 ％,74.5 ％,78.5 ％,78.7 ％ and 73.1 ％,respectively,superior to commercial fungicide fenfuram (70.5 ％).The EC50 values of the five tested compounds against R.solani showed that compound 1e exhibited the most potent inhibition with an EC50value of 2.824 mg/L which lower than that of fenfuram (EC50 =7.691 mg/L).As a result,compound 1e could be a lead compound forfurther research.关键词
2-甲基-3-呋喃甲酰胺类/合成/抑菌活性/EC50Key words
2-methyl-3-furancarboxamide derivatives/Synthesis/Antifungal activity/EC50分类
农业科技引用本文复制引用
蒲桃,王宏宇,刘英,金洪,陶科,侯太平..新型2-甲基-3-呋喃甲酰胺类化合物的设计、合成及抑菌活性研究[J].四川大学学报（自然科学版）,2017,54(1):178-184,7.基金项目
国家自然科学基金(31272068) （31272068）
