上海针灸杂志2017，Vol.36Issue(4)：473-477,5.DOI:10.13460/j.issn.1005-0957.2017.04.0473
电针抗下肢肌萎缩的频率组合优化及其机制的初步研究
A Preliminary Study of the Optimal Frequency Combination and Mechanism of Electroacupuncture Treatment for Lower Limb Myatrophy
摘要
Abstract
Objective To sift out the optimized electric pulse parameters for electroacupuncture treatment for lower limb myatrophy and explore the mechanism of its treatment.Method A model of lower limb myatrophy was made in 40 SD rats.The rats were then randomized to groups A (model group without electroacupuncture), B (a pulse duration of 0.5 ms and a frequency of 2 Hz), C (a pulse duration of 200 msand a frequency of 2 Hz) and D (a pulse duration of 200 ms and a frequency of 1/2/3 Hz).Points Zusanli(ST36)and Chengshan(BL57)were given electroacupuncture for four courses of treatment.Thesciaticfunction index (SFI),gastrocnemius muscle wet weight ratio (GW), gastrocnemius muscle fiber cross-sectional area ratio (GC),gastrocnemius muscle cell diameter ratio (GD)and gastrocnemius muscle cell apoptosis index (AI)were determined.Result SFI, GW and GC increased significantly and AI decreased significantly in groups C and D compared with group A (P<0.05). AI decreased significantly in groups C and D compared with group B (P<0.05). AI decreased significantly in groups D compared with group C (P<0.05). Conclusion Apulse duration of 200 ms and a frequency of 1/2/3 Hz are the optimizedelectric pulse parametersfor electroacupuncture delaying myatrophy.Its mechanism is related to inhibiting myocyte apoptosis.关键词
针刺/电针/波宽/频率/肌萎缩/细胞凋亡/大鼠Key words
Acupuncture/Electroacupuncture/Pulsewidth/Frequency/Myatrophy/Apoptosis/Rats分类
医药卫生引用本文复制引用
庄伊洢,黄晓卿,叶笑然,陈玄..电针抗下肢肌萎缩的频率组合优化及其机制的初步研究[J].上海针灸杂志,2017,36(4):473-477,5.基金项目
国家自然科学基金面上项目(81373733) （81373733）
福建省属公益类科研院所基本科研专项(2015R1035-4) （2015R1035-4）
