世界中医药2017，Vol.12Issue(1)：142-146,151,6.DOI:10.3969/j.issn.1673-7202.2017.01.036
脉抒对高脂血症金黄地鼠血脂及血管内皮功能的影响
Effect of MaiShu on Blood Lipid Levels and vascular endothelial function in Golden Hamster with Hyperlipidemia
摘要
Abstract
Objective:To observe the effect of Maishu on blood lipid and vascular endothelial function in golden hamster with hyperlipidemia.Methods:The model of golden hamster with hyperlipidemia was induced by a high fat diet and administrated with MaiShu (low dosage:1 g/kg/d,middle dosage:2 g/kg/d,high dosage:14 g/kg/d).Changes of serum TC,TG,HDL-C and nonHDL-C levels were observed after 2,4,8weeks treatment.Serum VLDL,LDL and HDL were separated by FPLC technique after for 8-week treatment and the level of cholesterol in VLDL,LDL,HDL;testing liver index and TC,TG level in liver were tested.The viscosity of whole blood was measured by the automatic blood viscosity meter.The changes of the endothelium-dependent relaxing reaction of golden hamster mesenteric arteriolar induced by acetylcholine was observed to assess the effect of MS on vascular endothelial function.Results:MS high and middle dose have the function to decrease serum TC level of hamster with hyperlipidemia after 2,4,8 weeks treatment (P ＜0.01,P ＜0.01,P ＜0.05,P ＜0.01,P ＜0.01,P ＜0.01) and the TC level in serum VLDL,LDL,HDL (P ＜ 0.05,P ＜ 0.01).It also can lower the TC (P ＜ 0.01,P ＜ 0.05,TG level in hamster liver,inhibit liver index (P ＜ 0.01,P ＜ 0.05),improve the whole blood visocity of middle cut (P ＜ 0.01,P ＜ 0.05) and high cut (P ＜ 0.05,P ＜ 0.05).Middle dose of MS can also improve the vasodilation function of mesenteric arteriolar in golden hamster model with hyperlipidemia.Conclusion:MS has the function of improving blood lipid,whole blood visocity and vascular endothelial relaxation function in hamster with hyperlipidemia.关键词
脉抒/高脂血症/药效学研究Key words
MS/Hyperlipidemia/Pharmacodynamics study分类
医药卫生引用本文复制引用
范佳文,王青春,董文婕,高林,黄永刚,朱海波..脉抒对高脂血症金黄地鼠血脂及血管内皮功能的影响[J].世界中医药,2017,12(1):142-146,151,6.基金项目
国家“重大新药创制”科技重大专项资助项目(编号:2012ZX09301002-004) （编号:2012ZX09301002-004）
