世界中医药2017，Vol.12Issue(3)：509-512,4.DOI:10.3969/j.issn.1673-7202.2017.03.007
慢性束缚应激抑郁症大鼠海马Belin-1、LC3的表达变化及逍遥散的调节作用
Effects of Xiaoyaosan Decoction on the expression of Belin-1 and LC3 inhippocampus of rats with depression induced by chronic restraint stress
摘要
Abstract
Objective:To observe the effects of Xiaoyaosan Decoction on the expression of Belin-1 and LC3 in hippocampus of rats with depression induced by chronic restraint stress.Methods:A total of 20 Wistar rats were randomly divided into 4 groups:the control groupthe model groupthe Xiaoyaosan (XYS) group and the fluoxetine group.Depression model was established by 21-day chronic restraint stressand the expression of Belin-1 and LC3 in CA3 of rats′ hippocampus was detected by immunohistochemistry.Results:There is significant differences between the control group and other groups (P<0.05).Xiaoyaosan Decoction could down-regulated the expression of Belin-1 and LC3 (P<0.05).Conclusion:The expression of Belin-1 and LC3 in hippocampus of rats with depression induced by chronic restraint stress indicated that autophagy may be part of the mechanism of depression.The effect of Xiaoyaosan Decoction on depression could be related to the regulation of Belin-1 and LC3.关键词
逍遥散/抑郁症/自噬/Beclin-1/LCAKey words
Xiaoyaosan Decoction/Depression/Autophagy/Beclin-1/LCA分类
医药卫生引用本文复制引用
王亭晔,李晓娟,周雪明,潘秋霞,陈家旭..慢性束缚应激抑郁症大鼠海马Belin-1、LC3的表达变化及逍遥散的调节作用[J].世界中医药,2017,12(3):509-512,4.基金项目
国家自然科学基金项目(编号:81473597 （）
81630104) （）
北京市自然科学基金项目(编号7152093) （编号7152093）
