世界中医药2017，Vol.12Issue(3)：562-565,569,5.DOI:10.3969/j.issn.1673-7202.2017.03.021
慢性乙型肝炎患者中医证型与ALT、HBV DNA及肝组织病理的关系
The Relationship between TCM Syndrome Types and ALTDNA HBV and Liver Tissue Pathology in Patients with Chronic Hepatitis B
摘要
Abstract
Objective:To investigate the relationship between TCM syndromes and liver functionserum virologyimmunohistochemical HBsAgHBcAg detection rate and liver histopathology in patients with chronic hepatitis B (CHB) and its diagnostic significance for CHB.Methods:Fifty-eight cases of CHB patients who were hospitalized in our department from June 2013 to August 2016 were selectedcomparing the relationship between different TCM syndromes and liver functionHBVDNA levelimmunohistochemical HBsAgHBcAg detection rate and liver histopathology.Results:1)TCM syndrome differentiation:liver depression and spleen deficiency syndrome (26 / 58,31%) and damp-heat syndrome (15 / 58,30%) appeared with the highest frequencyfollowed by liver and kidney yin deficiency syndrome (7/5815%)spleen and kidney yang deficiency (6 / 58,12%) and blood stasis in collaterals syndrome (4 / 58,12%);2)different TCM syndromes and ALT were significantly correlatedwith significant difference in comparison (P<0.05);there was no significant correlation between different TCM syndromes and AST and TBILand no statistical difference (P>0.05);3)different TCM syndromes and HBV DNA were significantly correlatedwith significant difference in comparison (P<0.05);there was no significant correlation between HBsAg and HBeAg in different TCM syndromeswith no statistical difference (P<0.05);4)there was correlation between different TCM syndromes and immunohistochemical HBcAg detection rate (P<0.05) with various groups shared significant differencewhile not between different TCM syndromes and immunohistochemical HBsAg detection rate (P>0.05);5)liver inflammation G and fibrosis degree S of CHB patients were highly correlated,(r=0.758P<0.01);different TCM syndromes and liver inflammation G were significantly correlated (P<0.05);different TCM syndromes and fibrosis Degree S was significantly correlated (P<0.01).Conclusion:The detection rate of ALTHBV DNAimmunohistochemical HBcAg and liver inflammation G and fibrosis degree S in CHB patients are significantly correlated with TCM syndromeswhich is of great significance to guide the clinical diagnosis and treatment of CHB patients.关键词
慢性乙型肝炎/中医证型/肝功能/HBVDNA/肝组织病理Key words
Chronic hepatitis B/TCM syndromes/Lliver function/HBV DNA/Liver histopathology分类
医药卫生引用本文复制引用
刘丽丽,张国梁,刘永华,窦红漫,武松..慢性乙型肝炎患者中医证型与ALT、HBV DNA及肝组织病理的关系[J].世界中医药,2017,12(3):562-565,569,5.基金项目
安徽省自然科学基金项目(编号:1408085QH185) （编号:1408085QH185）
