世界中医药2017，Vol.12Issue(3)：591-594,4.DOI:10.3969/j.issn.1673-7202.2017.03.029
健脾清热活血方治疗溃疡性结肠炎对肠黏膜屏障修复的随机对照研究
Randomized Controlled Study of Jianpiqingrehuoxue Decoction in Treating Ulcerative Colitis on Intestinal Mucosal Barrier Repair
赵文韬 1吴金萍 2王业皇2
作者信息
- 1. 南京中医药大学,南京,210029
- 2. 南京中医药大学第三附属医院,南京,210001
- 折叠
摘要
Abstract
Objective:To investigate the curative effect of Jianpiqingre Huoxue Decoction on ulcerative colitis (UC) and its effect on intestinal mucosal barrier repair.Methods:A total of 86 UC patients were randomly divided into observation group (n=43) and control group (n=43) by randomized controlled design.The control group was treated with conventional western medicinethe observation group combined with the traditional Chinese medicine Jianpiqingrehuoxue Decoction treatment2 groups were treated for 12 weeks.Before and after treatmentthe changes of intestinal mucosa functionserum related indexes and symptoms of TCM were compared.The clinical effective rate and relapse rate of the 2 groups were statistically analyzed.Results:The levels of lactulose (LAC)lactulose/mannitol (L/M)serum endotoxin (ET)diamine oxidase (DAO) and procalcitonin (PCT) were lower than before treatment (P<0.05 or P<0.01)and the observation group was significantly lower than the control group (P<0.01).The score of ulcercongestionedemaerosion and diarrhea in the observation group were significantly lower than those in the control group (P<0.01).After treatmentthe total effective rate of the observation group (93.02%) was significantly higher than the control group (76.74%) (P<0.05).During Follow-up period3 cases (6.70%) in the observation group and 8 cases (18.60%) relapsed in the control groupthere was significant difference in recurrence rate between the 2 groups (P<0.05).Conclusion:Jianpi qingrehuoxue Decoction can improve the healing quality of intestinal mucosarelieve the clinical symptomsand relapse rate is lowit is worthy of clinical application.关键词
溃疡性结肠炎/健脾清热活血类方药/肠黏膜功能/随机对照研究Key words
Ulcerative colitis/Jianpiqingrehuoxue Decoction/Intestinal mucosa function/Randomized controlled study分类
医药卫生引用本文复制引用
赵文韬,吴金萍,王业皇..健脾清热活血方治疗溃疡性结肠炎对肠黏膜屏障修复的随机对照研究[J].世界中医药,2017,12(3):591-594,4.
