食品科学2017，Vol.38Issue(5)：262-266,5.DOI:10.7506/spkx1002-6630-201705043
佛手山药多糖对2型糖尿病大鼠糖脂代谢及氧化应激的影响
Effect of Dioscorea opposita Thunb.Polysaccharide on Glycolipid Metabolism and Oxidative Stress in Type 2 Diabetic Rats
植飞 1邢琪昌 2汪莹 1蔡羽 1颜春潮 1陈运中1
作者信息
- 1. 湖北中医药大学药学院,湖北武汉 430065
- 2. 武汉轻工大学生物与制药工程学院,湖北武汉 430023
- 折叠
摘要
Abstract
Objective:To investigate the effect of Dioscorea opposita Thunb.polysaccharide (DTP) extracted from the rhizomes of the ‘Foshou’ cultivar on glycolipid metabolism and oxidative stress in type 2 diabetic rats.Methods:A rat model of type 2 diabetes mellitus (T2DM) was constructed by feeding SD rats a high-fat diet and intrapefitoneal injection of streptozocin into them at a dose of 40 mg/kg.The model rats were randomly divided into model control group (MC),positive control group (PC) (metformin at 150 mg/(kg·d)),DTP group (400 mg/(kg.d)),and normal control group (NC).During an administration period of six weeks,the general condition of rats was observed.Body weight,hepatic glycogen,blood glucose,and triacylglyceride (TG),low density lipoprotein cholesterol (LDL-C),HDL-C,malonaldehyde (MDA),nitric oxide (NO) and the activties of superoxide dismutase (SOD),catalase (CAT),glutathione peroxidase (GSH-Px) in serum were tested.Results:Compared with the model group,DTP effetively lowered fasting blood glucose levels in rats with experimental T2DM,highly significantly reduced serum TC and LDL-C levels,significantly decreased serum TG levels,and significantly enhanced the activities of SOD and CAT,but it had no significant impacts on hepatic glycogen,serum HDL-C,MDA and NO levels or serum GSH-Px activity.Conclusion:DTP shows a significant hypoglycemic effect on T2DM rats,and can regulate lipid metabolic disorders and the underlying mechanism may be associated with the enhanced activities of CAT and SOD.关键词
佛手山药/多糖/2型糖尿病/血糖/血脂Key words
Dioscorea opposita Thunb./polysaccharide/type 2 diabetes/blood glucose/blood lipids分类
医药卫生引用本文复制引用
植飞,邢琪昌,汪莹,蔡羽,颜春潮,陈运中..佛手山药多糖对2型糖尿病大鼠糖脂代谢及氧化应激的影响[J].食品科学,2017,38(5):262-266,5.
