实用妇产科杂志2017，Vol.33Issue(3)：185-188,4.
内皮型一氧化氮合酶表达及微血管密度评估体外受精患者子宫内膜容受性的价值
The Value of Endothelial Nitric Oxide Synthase Expression and Microvessle Density on Assessing the Endometrial Receptivity of IVF Patients
摘要
Abstract
Objective:To evalute the effects of expressions of endothelial nitric oxide synthase (eNOS) and microvessle density(MVD) in endometrial receptivity of IVF-ET patients.Methods:A total of 60 cases of IVF-ET patients during the implantation window before the IVF cycle were selected for endometrial sampling,immunohistochemistry was used to detect the expression of eNOS protein and MVD,reverse transcription polymerase chain reaction to detect the expression of eNOS mRNA.According to the clinical pregnancy outcome,patients was divided into pregnant group(30 cases) and non-pregnant group(30 cases) and comparing the mRNA and protein of eNOS、MVD between the two groups.Results:The eNOS mRNA in the pregnant group(0.72 ±0.21) was significantly higher than that in non-pregnant group (0.29 ± 0.12),the difference was statistically significant (P ＜0.05);The positive expression rate of eNOS protein in the pregnant group(80.0％) was significantly higher than that in non-pregnant group(13.3％),the difference was statistically significant(P ＜0.05);The MVD in the pregnant group(14.53 ±3.28) was significantly higher than that in non-pregnant group(12.20-±3.83),the difference was statistically significant(P ＜ 0.01);The endometrial eNOS expression level was positively correlated with MVD (r=0.814;P＜0.05).Conclusions:The up-regulated expression of MVD、eNOS m RNA and protein during implantation window phase could help to improve the endometrial receptivity and increase embryo implantation chance.关键词
内皮型一氧化氮合酶/子宫内膜容受性/体外受精-胚胎移植/着床窗口期/微血管密度Key words
Endothelial nitric oxide synthase/Endometrial receptivity/In vitro fertilization-embryo transferm/Implantation window phase/Microvessle density分类
医药卫生引用本文复制引用
王楠,张坪,赵永玲,江乾,甄秀丽..内皮型一氧化氮合酶表达及微血管密度评估体外受精患者子宫内膜容受性的价值[J].实用妇产科杂志,2017,33(3):185-188,4.基金项目
河北省卫计委医学科学研究重点课题计划(编号:20150304 （）
ZD20140141) （）
