沈阳工业大学学报2017，Vol.39Issue(2)：230-235,6.DOI:10.7688/j.issn.1000-1646.2017.02.20
邻苯二甲酸二丁酯的毒性作用及机制
Toxic effect and mechanisms of dibutyl phthalate
摘要
Abstract
Aiming at the current situation that the environmental pollution has become increasingly serious, the effect of dibutyl phthalate (DBP) on the hepatotoxicity and reproductive toxicity was studied.The key enzymes, sperm viability and sperm abnormality rate were tested, and the pathological changes of liver and testis were observed.The results show that DBP can significantly raise the glutamic-pyruvic transaminase (GPT), glutamic-oxaloacetic transaminase (GOT), alkaline phosphatase (AKP) and malonaldehyde (MDA), and remarkably reduce the superoxide dismutase (SOD) and catalase (CAT).It means that DBP can induce the lipid peroxidation of liver for mice and early hepatic injury.BPA can penetrate blood-testis barrier, and interfere the growth and development process of sperms.Therefore, DBP is a genotoxic compound which has latent mutagenic damage to the malesex cells.关键词
邻苯二甲酸二丁酯/肝脏毒性/生殖毒性/脂质过氧化损伤/血睾屏障/精子活力/精子畸形率/病理改变Key words
dibutyl phthalate(DBP)/hepatotoxicity/reproductive toxicity/lipid peroxidation injury/blood-testis barrier/sperm viability/sperm abnormality rate/pathological change分类
化学化工引用本文复制引用
纪红蕊,杜霞,宋永彬,刘欣..邻苯二甲酸二丁酯的毒性作用及机制[J].沈阳工业大学学报,2017,39(2):230-235,6.基金项目
国家自然科学基金资助项目(21476054). （21476054）
