生殖医学杂志2017，Vol.26Issue(4)：345-350,6.DOI:10.3969/j.issn.1004-3845.2017.04.011
GnRH拮抗剂方案中雌激素预处理与正常反应患者临床结局的Meta分析
Meta-analysis of estrogen pretreatment in ovarian stimulation with GnRH antagonists for IVF
摘要
Abstract
Objective:To conducted an updated meta-analysis of the efficacy of oral estrogen pretreatment on pregnancy outcome in GnRH antagonist cycles.Methods:All the estrogen pretreatment in GnRH antagonist regimen of randomized controlled trials from 1984 to 2014 were systematically searched with the terms of "estrogen","in vitro fertilization" and "GnRH antagonist" from PubMed/MEDLINE,EMBASE,Cochrane Library,Wiley Library,Web of Science,ScienceDirect database,the Chinese Academic Journal,WanFang DATA,VIP database,Chinese Biomedical Literature Database.Results:Four randomized controlled trials were included.Compared with the GnRH antagonist group without estrogen pretreatment,the duration of gonadotropin [MD 0.87,95% CI:(0.55,1.19)],total doses of gonadotropin [MD 197.45,95% CI:(164.43,230.47)],and number of oocytes retrieved [MD 1.49,95% CI:(0.44,2.53)] were significantly increased (all P<0.01) in the GnRH antagonist with estrogen pretreatment;while the ongoing pregnancy rate [RR=0.90,95% CI:(0.71,1.16),P=0.43],clinical pregnancy rate [OR=0.90,95% CI:(0.65,1.25),P=0.54],live birth rate[OR=0.8,95% CI:(0.54,1.20),P=0.28] and abortion rate [OR=0.82,95% CI:(0.42,1.60),P=0.56] were not significantly different (P>0.05).Conclusions:Estrogen pretreatment does not affect the clinical pregnancy rate,live birth rate and abortion rate,but increase oocytes retrieved.The estrogen pretreatment is an optional method to facilitate cycle control without affecting pregnancy outcome.关键词
体外受精-胚胎移植/GnRH拮抗剂/雌激素/临床结局Key words
IVF-ET/GnRH antagonist/Estrogen/Clinic outcome引用本文复制引用
易思思,梁新红,丘映..GnRH拮抗剂方案中雌激素预处理与正常反应患者临床结局的Meta分析[J].生殖医学杂志,2017,26(4):345-350,6.基金项目
广西科学研究与技术开发计划项目(桂科攻0993003A-32) （桂科攻0993003A-32）
