生殖医学杂志2017，Vol.26Issue(4)：377-381,5.DOI:10.3969/j.issn.1004-3845.2017.04.018
HIF-1α在子宫内膜异位症中的研究进展
Research progress of HIF-1α in endometriosis
摘要
Abstract
Endometriosis (EMs) is a common gynecologic disorder affecting 10-15% of women in reproductive age.However,the underlying etiology of the disease is still poorly understood.In recent years,a growing body of evidence validated that hypoxia developed a close relationship with EMs,and the expression of hypoxia inducible factor-1alpha (HIF-1α) was significantly increased in development of EMs.HIF-1α contributed to endometriosis by regulating the genes which were essential to estrogen production,angiogenesis,proliferation and inflammation.In addition,HIF-1α is a key regulator in the process of aerobic glycolysis in EMs.Furthermore,inhibition of the expression of HIF-1α contributed to suppress EMs progression,suggesting HIF-1α plays a critical function in EMs.This paper reviews the research progress of HIF-1α and its role in endometriosis.关键词
子宫内膜异位症/低氧诱导因子-1α/雌激素/血管生成/有氧糖酵解Key words
Endometriosis/HIF-1α/Estrogen/Angiogenesis/Aerobic glycolysis引用本文复制引用
朱媛媛,崔毓桂,冒韵东..HIF-1α在子宫内膜异位症中的研究进展[J].生殖医学杂志,2017,26(4):377-381,5.基金项目
国家自然科学基金(81200424) （81200424）
江苏省卫生厅妇幼保健重点学科(FXK201221) （FXK201221）
江苏省妇幼保健重点人才(FRC201215) （FRC201215）
江苏省科技厅临床医学科技专项(BL2012009) （BL2012009）
