天津中医药2017，Vol.34Issue(4)：259-261,3.DOI:10.11656/j.issn.1672-1519.2017.04.14
乌头汤对DPN大鼠NGF受体TrkA、p75NTR表达的影响
Intervention of Aconite Main Tuber decoction on NGF,TrkA and p75NTR in rats developed diabetic peripheral neuropathy
崔翰博 1褚月颉 1任永丽 1李萍1
作者信息
- 1. 天津市中医药研究院附属医院糖尿病科,天津 300120
- 折叠
摘要
Abstract
[Objective] To study the effect and mechanism of Aconite Main Tuber Decoction on NGF ,TrkA and p75NTR in rats developed diabetic peripheral neuropathy(DPN). [Methods] To set up pathological model of DPN, wistar rats were given streptozotocin (STZ) by intraperitioneal injection. NGF in serum and TrkA, p75NTR in tibial nerve tissue were observed. [Results] Compared with blank control group, FBG were higher in both before and after the intervention groups and Aconite Main Tuber Decoction group (P<0.01). No significant difference in FBG within the groups before and after intervention (P>0.05). Compared with model control group, NGF in serum were higher and p75NTR in tissue were lower in medicinal group (P<0.05). In medicinal group,immunohistochemistry showed a lower degree positive staining compared with model control. [Conclusion] Aconite Main Tuber Decoction could alleviate DPN by regulating p75NTR/TrkA balance and rising NGF concentration.关键词
乌头汤/糖尿病周围神经病变/神经生长因子/酪氨酸蛋白激酶A/p75神经营养因子受体Key words
Aconite Main Tuber decoction/diabetic peripheral neuropathy/nerve growth factor/TrkA/75NTR分类
医药卫生引用本文复制引用
崔翰博,褚月颉,任永丽,李萍..乌头汤对DPN大鼠NGF受体TrkA、p75NTR表达的影响[J].天津中医药,2017,34(4):259-261,3.
