天津中医药2017，Vol.34Issue(4)：280-284,5.DOI:10.11656/j.issn.1672-1519.2017.04.19
血小板ADP受体及其拮抗剂的研究进展
Research progress of platelet ADP receptor and its antagonist
摘要
Abstract
Adenosine diphosphate (ADP) is the first known low molecular weak platelet aggregation inducer. It is stored in platelet dense granules with high concentration. When the platelets were stimulated, ADP was released from the dense particles . As a secondary agonist, it can strengthen induction on itself and other revulsants. ADP contributes to stabilize thrombus by acting on a variety of receptors. Antagonists of ADP receptor can inhibit the expression and activation of ADP receptor, and can also inhibit platelet aggregation effectively. The antagonist plays an important role in treating thrombotic diseases. Currently, as ADP receptor antagonists have good antithrombotic activity and higher safety, it has been widely used in clinic. The data of different types of ADP receptor and some important receptor antagonists were reviewed in this study. We intent to provide a certain guide in the development of ADP receptor antagonists.关键词
血小板/P2Y1受体/P2Y12受体/P2X1受体/拮抗剂Key words
platelet/P2Y1 receptor/P2Y12 receptor/P2X1 receptors/antagonists分类
医药卫生引用本文复制引用
翟婷,华声瑜..血小板ADP受体及其拮抗剂的研究进展[J].天津中医药,2017,34(4):280-284,5.基金项目
国家自然科学基金项目(81202798) （81202798）
国家自然基金项目(81473381). （81473381）
