天津中医药大学学报2017，Vol.36Issue(2)：113-116,4.DOI:10.11656/j.issn.1673-9043.2017.02.09
芪明颗粒对早期糖尿病肾病炎症因子及尿微量白蛋白的影响
Effect of Qiming Granule on inflammatory factors and urinary micro albumin in early diabetic nephropathy
摘要
Abstract
[Objective] To explore the mechanism of early diabetic nephropathy by observing the effect of Qiming Granule on the inflammatory factors and urinary albumin in early diabetic nephropathy. [Methods] Selected in accordance with the inclusion criteria of patients with early diabetic nephropathy in 120 cases, using the random number table method 60 patients were divided into treatment group and control group of 60 cases, 2 groups were treated with routine treatment and care, the treatment group to the Qiming Granule 1 bag each time, 3 times a day, the control group was given time a day Valsartan capsules 80 mg on the changes of the two groups were observed in patients with hs-CRP, IL-6, IL-1β, TNF-α, and alpha beta 24 h UmAlb after 16 weeks of treatment. [Results] The total effective rate of the treatment group and the control group were 91.67%and 76.67%, and there were significant differences (P<0.05). The two groups before and after treatment in patients with inflammatory factors have improved, but the control group had no statistical significance in hs-CRP, IL-6, IL-1β, TNF-αaspect(P>0.05), the treatment group in hs-CRP, IL-6, IL-1βand TNF-αcomparison with the control group there were significant differences (P<0.05)in 24 h UmAlb group, the groups were statistically significant(P<0.05)before and after treatment, after treatment was not statistically significant(P>0 . 05). [ Conclusion ] Qiming Granule in improving early diabetic nephropathy TCM symptoms, inflammatory factors is better than the control group, but also can significantly improve the urinary albumin, can delay the development of diabetic nephropathy. Qiming Granule is safe and effective in the treatment of early diabetic nephropathy, which provides the experimental basis for the clinical application of Qi Ming Granule.关键词
芪明颗粒/糖尿病肾病/炎症因子/尿微量白蛋白Key words
Qiming Granule/diabetic nephropathy/inflammatory factor/urinary albumin分类
医药卫生引用本文复制引用
王军媛,赵建红,刘颖,张军,李振,臧乐红,王玉红..芪明颗粒对早期糖尿病肾病炎症因子及尿微量白蛋白的影响[J].天津中医药大学学报,2017,36(2):113-116,4.基金项目
2014年度河北省中医药管理局科学技术课题(2014101). （2014101）
