天然产物研究与开发2017，Vol.29Issue(2)：190-197,8.DOI:10.16333/j.1001-6880.2017.2.002
锡尾矿链霉菌AE21985代谢产物的分离与鉴定
Secondary Metabolites of Tin Tailings Streptomyces AE21985
摘要
Abstract
19 Compounds were isolated from liquid fermentation of Streptomyces AE21985 with ordinary silica gel chromatography,gel column chromatography and preparative HPLC.With the spectroscopic methods,they were identified as eleven cyclic dipeptide compounds:3-(4-hydroxybenzyl)-6-(1H-indol-3-ylmethyl) piperazine-2,5-dione (1),(3S,6S)-3-((R)-sec-butyl)-6-methylpiperazine-2,5-dione (2),(3S)-3-benzylpiperazine-2,5-dione (3),(3S,6S)-3-(2-methylpropyl)-6-(propan-2-yl) piperazine-2,5-dione (4),3-Isobutylhexahydropyrrolo [1,2-a] pyrazine-1,4-dione (5),(3S,6S)-3-((R)-sec-butyl)-6-methylpiperazine-2,5-dione (6),(3S,6S)-3-isopropyl-6-methylpiperazine-2,5-dione (7),(3 S,7R,9S)-7-hydroxy-3-isobutylhexahydropyrrolo [1,2-a] pyrazine-1,4-dione (8),3-(1H-indol-3-ylmethyl)-6-(propan-2-yl) piperazine-2,5-dione (9),(3S,8aS)-3-(propan-2-yl) hexahydropyrrolo [1,2-a] pyrazine-1,4-dione (10) and (3 S,6S)-3-benzyl-6-methylpiperazine-2,5-dione (11);five lactam compounds:(2E)-3-phenylprop-2-enamide (12),3-phenylpropanamide (13),2-phenylacetamide (14),benzamide (15) and 3-(1H-indol-3-yl) propanamide (16);an alkaloid compound:1H-indole-5-carbaldehyde (17) and two nucleoside compounds:uridine (18) and thymine (19).All the compounds were discovered from this strain for the first time.关键词
链霉菌/TLC筛选/分离纯化/结构鉴定Key words
Streptomyces/TLC screening/isolation/structural elucidation分类
医药卫生引用本文复制引用
程举,李铭刚,丁章贵,文孟良,赵江源..锡尾矿链霉菌AE21985代谢产物的分离与鉴定[J].天然产物研究与开发,2017,29(2):190-197,8.基金项目
国家自然科学基金(B020901,31260012,21402169) （B020901,31260012,21402169）
云南省人才项目(2011CI001) （2011CI001）
