天然产物研究与开发2017，Vol.29Issue(2)：235-239,5.DOI:10.16333/j.1001-6880.2017.2.009
忽地笑内生青霉菌GZWMJZ-39次生代谢产物研究
Secondary Metabolites of Endophytic Penicillium cavernicola GZWMJZ-39 from Lycoris aurea Herb
摘要
Abstract
In order to investigate bioactive metabolites from endophytic fungi,a fungal strain GZWMJZ-39 was isolated and identified as Penicillium cavernicola from the bulb of Lycoris aurea Herb in Guiyang Guizhou,China.The fermentation extract was purified by column chromatography over silica gel,Sephadex LH-20 and semi-preparative HPLC.The structures of isolated compounds were identified by NMR and MS.As a result,six compounds,peniginseng B (1),peniginseng A (2),4-(3,4-dihydroxybenzamido) butanoic acid (3),methyl 4-(3,4-dihydroxybenzamido) butanoate (4),peniamidone B (5) and chaetoglobosin G (6),were obtained.Compounds 1-5 exhibited good radical scavenging activities against DPPH with IC50 values ranged from 3.9 to 27.4 μM.Compound 1-6,at a concentration of 50 μg/mL,showed weak inhibitory activity against AChE with inhibition rates from 25.2％ to 32.6％,respectively.关键词
忽地笑/内生真菌/代谢产物/抗氧化/乙酰胆碱酯酶Key words
Lycoris aurea Herb/endophytic fungi/secondary metabolites/antioxidant/AChE分类
医药卫生引用本文复制引用
许言超,饶青,周彦伶,朱伟明,王立平..忽地笑内生青霉菌GZWMJZ-39次生代谢产物研究[J].天然产物研究与开发,2017,29(2):235-239,5.基金项目
黔科合院士站[2015] 4009号 （）
黔科合体Z字[2014]4007号 （）
