天然产物研究与开发2017，Vol.29Issue(2)：268-272,5.DOI:10.16333/j.1001-6880.2017.2.015
基于化学相似性搜索的丹酚酸A潜在靶点预测研究
Potential Targets of Salvianolic Acid A Predicted by Chemical Similarity Searching
摘要
Abstract
Salvianolic acid A (SAA) is a water-soluble component from Danshen.It plays many pharmacological roles in many diseases treatments with its potentialantioxidant activity.But its targets is still need to be illustrated.In this study,SwissTargetPrediction server was used to identify the potential targets of SAA by chemical similarity searching.The results showed that Src tyrosine family protein,such as Fyn and Src,may be the targets of SAA.Moreover,docking results showed SAA can interact with key residues of Fyn.In conclusion,Src tyrosine family protein,such as Fyn and Src,may be the potential targets of SAA.关键词
丹酚酸A/化学相似性搜索/酪氨酸蛋白激酶/靶蛋白Key words
salvianolic acid A/chemical similarity searching/tyrosine family protein/target protein分类
医药卫生引用本文复制引用
陈少军,董珂,陈宏降..基于化学相似性搜索的丹酚酸A潜在靶点预测研究[J].天然产物研究与开发,2017,29(2):268-272,5.基金项目
宁波市自然科学基金(2015A610280) （2015A610280）
校科研项目(ZPCSR2015018) （ZPCSR2015018）
