同位素2017，Vol.30Issue(1)：71-77,7.DOI:10.7538/tws.2017.30.01.0071
18F-DOPA制备研究进展
Research Progress in the Preparation of 18F-DOPA
摘要
Abstract
[18F]6-fluoro-3,4-dihydroxy-L-phenylalanine (18 F-DOPA) has been known to be a useful radiotracer for neuropsychiatric diseases and brain malignancies,and it is also abundantly used for visualizing neuroendocrine tumors at present.However,its more widespread clinical use was hampered by the lack of a high specific activity,high yielding labeling method.This review mainly summarized new developments in the synthesis of 18 F-DOPA with electrophilic reactions and nucleophilic substitution reactions in recent years.Among these,considerable advances in nucleophilic synthesis had been achieved by developing novel precursors and utilizing chiral phase-transfer catalysts (cPTC) mediated fluorinations allowing for the production of 18F-DOPA in high specific activity and high radiochemical yield.关键词
18F-DOPA/亲核取代/新型标记前体/手性相转移催化剂Key words
18F-DOPA/nucleophilic substitution/new precursor/chiral phase transfer catalyst分类
能源科技引用本文复制引用
贾丽娜,张岚..18F-DOPA制备研究进展[J].同位素,2017,30(1):71-77,7.基金项目
国家自然科学基金(11505269) （11505269）
