摘要
Abstract
Objective To study on epidural anesthesia and arousal time from dexmedetomidine in lower abdominal surgery. Methods A total of 120 cases with lower abdominal surgery under epidural anesthesia in our hospital were divi-ded into study group and control group from January 2015 to January 2016. Patients in study group received dexmedeto-midine anesthesia, and those in control group received clonidine anesthesia. The heart rate, mean arterial pressure, Ram-say sedation score, wakeup time and adverse reactions in different time segments between two groups were compared. Results The heart rate and mean arterial pressure at 15 min after loading dose in study group were lower than in control group (P=0.021 and P=0.033). No statistically significant difference was found at other time (P>0.05). The difference of Ramsay sedation score between two groups was not statistically significant (P>0.05). Bispectral index (BIS) in study group was significantly lower than that in control group (P<0.05). Arousal time, time for BIS to 90 and visual blur score of the patients in study group were significantly less than those in control group[(37.3±2.4) min, (39.1±5.1) min and (3.2±1.1) vs. (57.3±4.1) min, (58.2±3.2) min and (4.2±1.2), P<0.001]. Postoperative pain in study group[(198.2±33.2) min] delayed sig-nificantly compared with those in control group [(150.1±28.5) min] (P<0.001). The adverse reactions include bradycardia, hy-potension, nausea and vomiting, chills, and respiratory depression had no significant difference statistically in two groups (P>0.05). Conclusions Dexmedetomidine has better sedation and analgesia, shorter arousal time in lower abdominal surgery with epidural anesthesia, and does not increase the incidence of adverse reactions. The clinical application would be recommended.关键词
右美托咪定/可乐定/下腹部手术/硬膜外麻醉/唤醒时间Key words
Dexmedetomidine/Clonidine/Lower abdominal surgery/Epidural anesthesia/Arousa time分类
医药卫生
