物理化学学报2017，Vol.33Issue(4)：656-660,5.DOI:10.3866/PKU.WHXB201701162
基于多肽和温敏聚合物的光交联囊泡的制备及表征
Synthesis and Characterization of Thermo-Responsive Polypeptide-Based Vesicles with Photo-Cross-Linked Membranes
摘要
Abstract
It is an important challenge to balance the degradability and stability of polymer vesicles.We report a thermo-responsive vesicle based on poly[(N-isopropyl acrylamide-stat-7-(2-methacryloyloxyethoxy)-4-methylcoumarin)-b-(L-glutamic acid)] [P(NIPAM45-stat-CMA5)-b-PGA42] diblock copolymer,which was synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization and ring-opening polymerization (ROP).The membrane of the vesicle consists of thermo-responsive PNIPAM and photo-cross-linkable PCMA.The PGA chains in the vesicle coronas can colloidally stabilize the vesicles in water and can be postfunctionalized for further applications.Transmission electron microscopy and dynamic light scattering studies confirmed the formation of vesicles.Overall,we prepared a new functional thermo-responsive vesicle based on polypeptide copolymers that may be used as nanocarriers for the facile loading of a range of molecules in future.关键词
囊泡/多肽/胶囊/可逆加成断裂链转移聚合/N-羧基酸酐(NCA)Key words
Vesicle/Peptide/Polymersome/Reversible addition fragmentation chain transfer/N-carboxyanhydride (NCA)分类
化学化工引用本文复制引用
袁康,周雪,杜建忠..基于多肽和温敏聚合物的光交联囊泡的制备及表征[J].物理化学学报,2017,33(4):656-660,5.基金项目
The project was supported by the National Natural Science Foundation of China (21374080,21674081,21611130175),Shanghai International Scientific Collaboration Fund,China (15230724500),Shanghai 1000 Talents Plan,and Fundamental Research Funds for the Central Universities,China (0500219211,1500219107).国家自然科学基金(21374080,21674081,21611130175),上海市科委国际合作项目(15230724500),上海千人计划,中央高校基本科研业务费(0500219211,1500219107)资助项目 （21374080,21674081,21611130175）
