中国组织工程研究2017，Vol.21Issue(10)：1477-1482,6.DOI:10.3969/j.issn.2095-4344.2017.10.001
可膨胀椎弓根钉骨水泥强化与骨质疏松性胸腰椎固定强度的关系
Effect of expandable pedicle screw fixation on the fixation strength of osteoporotic thoracic and lumbar vertebrae
摘要
Abstract
BACKGROUND: Studies have shown that osteoporosis often leads to a failure in pedicle screw fixation. Considering that the use of ordinary pedicle screw fixation cannot achieve a strong and stable fixation of the osteoporotic vertebra,special measures to strengthen the internal fixation is indispensable.OBJECTIVE: To evaluate the effect of bone cement augmentation combined with expandable pedicle screw fixation on the fixation strength of osteoporotic thoracolumbar vertebrae.METHODS: Twenty osteoporotic thoracolumbar vertebral specimens were randomly divided into four groups: conventional pedicle screw group implanted with normal pedicle screw, and the other three groups implanted with expandable pedicle screw. Bone cement augmentation with polymethylmethacrylate (PMMA) and calcium sulfate was done in the PMMA group and calcium sulfate group, respectively, followed by expandable pedicle screw implantation. No bone cement was used in the expandable pedicle screw group. The maximum axial pull-out strength and yield energy absorption value of the unilateral pedicle were detected, and the maximum removal torque of the contralateral pedicle was determined. Bone cement leakage after augmentation was observed.RESULTS AND CONCLUSION: Compared with the conventional pedicle screw group, the other three groups showed a significant increase in the maximum pull-out strength, maximum removal torque and yield energy absorption values (P < 0.05). Moreover, these parameters were significantly higher in the PMMA and calcium sulfate groups than the expandable pedicle screw group and conventional pedicle screw group (P < 0.05), but there was no significant difference between the PMMA and calcium sulfate groups (P > 0.05). No leakage of bone cement was found in all the groups. To conclude, the combined use of expandable pedicle screw and can significantly enhance the stability of the osteoporotic thoracolumbar vertebrae, and the PMMA and calcium sulfate cements have similar effects.关键词
生物材料/骨生物材料/可膨胀椎弓根钉/骨水泥强化/硫酸钙/聚甲基丙烯酸甲酯/骨质疏松/固定强度分类
医药卫生引用本文复制引用
周庆忠,冯晓兰,张戈,贾叙锋,雷飞,叶飞,冯大雄..可膨胀椎弓根钉骨水泥强化与骨质疏松性胸腰椎固定强度的关系[J].中国组织工程研究,2017,21(10):1477-1482,6.基金项目
西南医科大学附属医院科研项目(15073) （15073）
西南医科大学科研项目(2015-YJ021) （2015-YJ021）
泸州市科技计划项目(2016-R-70(18/24)) （2016-R-70(18/24）
四川省卫生和计划委员会科研课题(2016PJ552) Funding:the Scientific Research Project of the Affiliated Hospital of Southwest Medical University, No. 15073 （2016PJ552）
the Scientific Research Project of the Southwest Medical University, No. 2015-YJ021 （）
the Science and Technology Plan of Luzhou City, No. 2016-R-70(18/24) （18/24）
the Scientific Research Project of Sichuan Provincial Health and Family Planning Commission, No. 2016PJ552 （）
