中国组织工程研究2017，Vol.21Issue(10)：1495-1500,6.DOI:10.3969/j.issn.2095-4344.2017.10.004
纳米羟基磷灰石/多元氨基酸共聚复合材料引导性骨再生膜管修复股骨大段骨缺损
Guided bone regeneration membrane tube made of nano-hydroxyapatite/multi(amino acid)copolymer in the repair of large segmental
摘要
Abstract
BACKGROUND: Treatment of large bone defects is an important problem faced by orthopedic physicians. Allogeneic bone transplantation is a classic method, but it has many restrictions. The membrane guided bone regeneration technique has become an important method for the research nowadays.OBJECTIVE:To compare the effects of self-made high strength biodegradable nano-hydroxyapatite/multi(amino acid) copolymer (n-HA/MACP) guided bone regeneration membrane tube and allograft bone graft segment in the repair of large segmental bone defect in goats. METHODS: The model of 30 mm large segment bone defect in the middle section of the femur in 32 adult goats was established. Experimental group used self-made n-HA/MACP tube to bridge defects following bone plate fixation. The control group was treated with allograft bone graft bone segments combined with plate fixation. The animals were sacrificed at 4, 8, 12 and 16 weeks after operation, and the bone callus growth was observed in the specimens. The X-ray and histological observations were performed at the same time. Biomechanical measurement of plate fixation of allograft cortical bone segment was done at 12 and 16 weeks after operation. RESULTS AND CONCLUSION: (1) After 4 to 16 weeks, gross and pathological results showed fibrous callus growth inside and outside of the membrane tube, and the fibrous callus gradually hardened into a bony callus. Additionally, the callus was larger in the experimental group than in the control group. X-ray films showed significantly increased lateral callus density in the experimental group as compared with the control group. (2) Maximum bending strength was significantly higher in the experimental group than in the control group at 16 weeks (P < 0.05). Overall, the n-HA/MACP membrane tube used for bridging large segment bone defects in goats can obtain similar repair effects to the allograft cortical bone, and further achieve the better mechanical strength of the new bone segment than the allograft bone.关键词
生物材料/骨生物材料/纳米羟基磷灰石/多元氨基酸共聚物/骨缺损/同种异体皮质骨段/骨移植分类
医药卫生引用本文复制引用
杨红胜,曹宗锐,严小虎,李育刚,许泽川,常山..纳米羟基磷灰石/多元氨基酸共聚复合材料引导性骨再生膜管修复股骨大段骨缺损[J].中国组织工程研究,2017,21(10):1495-1500,6.基金项目
四川省教育厅资助项目(CYZ12-008,13ZB0232) （CYZ12-008,13ZB0232）
四川省卫生和计划生育委员会资助项目(130395) （130395）
