中国组织工程研究2017，Vol.21Issue(10)：1508-1513,6.DOI:10.3969/j.issn.2095-4344.2017.10.006
米诺环素缓释剂对炎症根尖周渗出液中白细胞介素17表达的影响
Interleukin-17 in apical exudates of periapical periodontitis treated with minocycline controlled-release formulation
摘要
Abstract
BACKGROUND: Experimental proof for the efficacy, safety, and immunological assessment is needed when minocycline is used for root canal disinfection.OBJECTIVE: To investigate the effect of minocycline for root canal disinfection on levels of interleukin-17 in apical exudates of periapical periodontitis and periapical exudate volume.METHODS: Sixteen patients with acute periapical periodontitis (16 teeth) scheduled for root canal therapy were enrolled and randomly divided into calcium hydroxide and minocycline groups, respectively, followed by root canal disinfection.One week after disinfection, periapical index, periapical exudate volume and interleukin-17 level were detected prior to the root canal filling. Another 16 patients with normal pulp vitality (16 teeth) scheduled for single root canal filling were enrolled as control group, in which periapical index, periapical exudate volume and interleukin-17 level were detected.RESULTS AND CONCLUSION: The periapical exudate volume and interleukin-17 level in the calcium hydroxide and minocycline groups were significantly higher than those in the control group (P < 0.05). The periapical index and interleukin-17 level in the calcium hydroxide and minocycline groups were decreased significantly at 1 week after root canal disinfection (P < 0.05), while there was no difference between these two experimental groups in the periapical index, periapical exudate volume and interleukin-17 level. To conclude, the use of minocycline significantly reduces interleukin-17 level and periapical exudate volume, and thus achieves effective outcomes in periapical disease.关键词
生物材料/口腔生物材料/米诺环素/氢氧化钙/急性根尖周炎/白细胞介素17/根管治疗/根管消毒分类
医药卫生引用本文复制引用
贾智,杜雨,杜媛,姜晨..米诺环素缓释剂对炎症根尖周渗出液中白细胞介素17表达的影响[J].中国组织工程研究,2017,21(10):1508-1513,6.基金项目
天津市应用基础与前沿技术研究计划(一般项目)(15JCYBJC50200) Funding: the Application Foundation and Frontier Technology Research Program of Tianjin, No. 15JCYBJC50200 （一般项目）
