中国组织工程研究2017，Vol.21Issue(10)：1596-1603,8.DOI:10.3969/j.issn.2095-4344.2017.10.020
周围神经损伤后瓦勒氏变性及神经导管的研究与进展
Wallerian degeneration after peripheral nerve injury: research advance in nerve conduits
摘要
Abstract
BACKGROUND: How to promote the regeneration after peripheral nerve injury, especially after large defects, is a difficulty to be solved.OBJECTIVE: To review the mechanism of Wallerian degeneration and the development of nerve conduits.METHODS: PubMed database was searched for the literatures addressing the modular mechanism of Wallerian degeneration and nerve repair using the English keywords "peripheral nerve regeneration, Wallerian degeneration, nerve guidance conduits". A total of 74 eligible literatures were included based on the exclusion criteria.RESULTS AND CONCLUSION: Rat SARM1 and fruit fly dSARM have been found to be highly implicated in Wallerian degeneration, indicating that the changes of nicotinamide adenine nucleotide/nicotinamide adenine dinucleotide may be related to the activated SARM1. Whether delaying Wallerian degeneration is good or bad is still in dispute. The future study should focus on the early inhibition of Wallerian degeneration and promotion of neuroregeneration following peripheral nerve injury.关键词
生物材料/材料相容性/周围神经再生/瓦勒氏变性/神经导管/国家自然科学基金分类
医药卫生引用本文复制引用
苌彪,全琦,孙逊,刘若西,王玉,卢世璧,彭江..周围神经损伤后瓦勒氏变性及神经导管的研究与进展[J].中国组织工程研究,2017,21(10):1596-1603,8.基金项目
国家自然科学基金项目(51073024 （）
51273021) （）
973重点项目(2014CB542201 （）
2012CB518106) （）
军队"十三五"医学专项(BWS13C029) Funding: the National Natural Science Foundation of China, No. 51073024, 51273021 （BWS13C029）
the National Basic Research Program of China (973 Program), No. 2014CB542201, 2012CB518106 （973 Program）
the Special Project of the "Thirteenth Five-year Plan" for Medicine Development of Chinese PLA, No. BWS13C029 （）
