中国组织工程研究2017，Vol.21Issue(10)：1617-1622,6.DOI:10.3969/j.issn.2095-4344.2017.10.023
凝胶敷料用于骨外露创面的修复:创新与发展
Innovation and development of gel dressings in bone exposed wound repair
摘要
Abstract
BACKGROUND: Bone exposed wounds are frequently required to deal with in orthopaedic surgeries, involving the treatment of open fractures, bone tumors, osteomyelitis, and many other diseases, in which the defect of soft tissue caused by open fractures is the most difficult to deal with. Conventional debridement or negative pressure closed drainage technology is difficult to make bone exposed wounds heal, and the process is extremely cumbersome, during which,patients suffer a lot of pain.OBJECTIVE: To evaluate the advantages and disadvantages of the various types of dressings, and review the application of new hydrogel dressing in bone exposed wounds based on its advantages, such as keeping wound environment moisture, restoring skin physical barrier, contributing to routine dressing change.METHODS: A computer-based online retrieval of PubMed and CNKI databases was performed to search papers published between 2000 and 2016 using the key words "hydrogel dressing, bone exposed wound, traditional wound dressing, antibiotic" in English and Chinese, respectively. A total of 55 papers suitable for final analysis from the application of traditional and new dressings in bone tissue engineering were reviewed.RESULTS AND CONCLUSION: The treatment of bone exposed wounds involves the treatment of many diseases, such as open fractures, bone tumors, osteomyelitis, which is still an orthopedic problem to solve. The novel hydrogel dressings with unique advantages are able to provide better plans for bone exposed wounds, and the use of these dressings solves the regeneration and repair of exposed bone, and improves the infection of antibiosis. In addition, the gel dressings currently have become a hot spot of research because of the characteristics of sustained-release.关键词
生物材料/缓释材料/骨外露/创面愈合/传统敷料/水凝胶敷料/抗生素/生长因子/血管内皮生长因子/药物载体/国家自然科学基金分类
医药卫生引用本文复制引用
李文甜,涂计,高飞,刘国辉,邵增务,石磊,张祥林,熊蠡茗..凝胶敷料用于骨外露创面的修复:创新与发展[J].中国组织工程研究,2017,21(10):1617-1622,6.基金项目
国家重点研发计划(2016YFC1100100) （2016YFC1100100）
国家自然基金面上项目(81572204) （81572204）
华中科技大学研究生创新创业基金 （）
湖北省科技支撑计划(2015BHE014)Funding: the National Key Research and Development Program of China, No. 2016YFC1100100 （2015BHE014）
the General Project of National Natural Science Foundation of China, No. 81572204 （）
Graduates' Innovation Fund in Huazhong University of Science and Technology （）
Science and Technology Support Program of Hubei Province, No. 2015BHE014 （）
