中国组织工程研究2017，Vol.21Issue(11)：1641-1646,6.DOI:10.3969/j.issn.2095-4344.2017.11.001
强直性脊柱炎患者全髋关节置换后异位骨化的危险因素
Risk factors for heterotopic ossification following total hip arthroplasty in patients with ankylosing spondylitis
摘要
Abstract
BACKGROUND: Heterotopic ossification (HO) is common following primary total hip arthroplasty (THA) in patients with ankylosing spondylitis (AS), which may cause certain influence on functional recovery.OBJECTIVE: To explore the risk factors for HO after primary THA in AS patients.METHODS: The clinical and radiological data from 87 patients (132 hips) with AS undergoing primary THA between June 2011 and December 2015 were retrospectively analyzed, and followed up for more than 6 months. The radiological information included preoperative and postoperative hip anteroposterior and lateral radiographs. The presence of HO surrounding the prosthesis was evaluated on the radiographs at the last follow-up and graded according to the Brooker classification. Risk factors for HO were divided into invariable factors (age, sex, course and with or without ankylosed hip) and variable factors (preoperative C-reactive protein level, preoperative erythrocyte sedimentation rate, intraoperative blood loss, operation time, prosthesis types and anesthesia methods) to determine the pertinent risk factors.RESULTS AND CONCLUSION: (1) Totally 43 hips (32.6%) were found to have developed into HO. (2) Invariable risk factors including male (P=0.029), preoperative ankylosed hip (P < 0.001), and course (P=0.029) increased the prevalence of HO. Among the variable risk factors, prolonged operation time (P=0.031) and general anesthesia (P=0.003)were associated with the increased occurrence of HO. Age, preoperative C-reactive protein level and erythrocyte sedimentation rate, intraoperative blood loss, and prosthesis types had no obvious correlation with HO. (3) These results suggest that to prevent the formation of HO following THA in AS, efforts to reduce the operation time and avoid general anesthesia should be considered.关键词
骨科植入物/人工假体/强直性脊柱炎/全髋关节置换/异位骨化/危险因素/术前强直/手术时间/术中出血/麻醉方式/假体类型/国家自然科学基金分类
医药卫生引用本文复制引用
刘勇,霍少川,周驰,唐宏宇,陈德龙,陈建发,郭海,邓章荣,王海彬..强直性脊柱炎患者全髋关节置换后异位骨化的危险因素[J].中国组织工程研究,2017,21(11):1641-1646,6.基金项目
国家自然科学基金(KBC110134K11)"组蛋白去甲基化酶JMJD2蛋白家族在补肾法防治骨质疏松症中的作用机制" （KBC110134K11）
广东省自然科学基金(2015A030310203)"股骨头坏死症候异质性与其分子分型及临床MRI表现的相关性研究" the National Natural Science Foundation of China, No. KBC110134K11 （2015A030310203）
the Natural Science Foundation of Guangdong Province, No. 2015A030310203 （）
