畜牧兽医学报2017，Vol.48Issue(3)：393-402,10.DOI:10.11843/j.issn.0366-6964.2017.03.002
牛支原体逃避宿主免疫的研究进展
Advances in the Research of Immune Evasion by Mycoplasma bovis
摘要
Abstract
Mycoplasma bovis is considered to be one of the important pathogenic agents of cattle.It can persist in the host and causes a series of chronic diseases including bronchopneumonia,mastitis,otitis,genital disorders,arthritis,meningitis or keratoconjunctivitis.Due to the resistance to antibotic therapy and the lake of commercially available diagnostic tools and effective vaccines,M.bovis-induced diseases are difficult to prevent and control.The main reason of persisitent infection caused by M.bovis is to evade the host innate and adaptive immunity through high frequent variation of membrane surface antigens,avoiding phagocytosis,cell invasion,biofilm formation and modulating host immune responses.Deeply understanding immune evasion mechanism of M.bovis is helpful to develop the new dignostic tools and novel vaccines,and it is also beneficial to prevent and control the diseases.关键词
牛支原体/免疫逃避/抗原变异/规避吞噬/生物膜/免疫调节Key words
Mycoplasma bovis/immune evasion/antigenic variation/avoiding phagocytosis/biofilm/immunoregulation分类
农业科技引用本文复制引用
季文恒,储岳峰,赵萍,陈胜利,郝华芳,王展慧,刘永生..牛支原体逃避宿主免疫的研究进展[J].畜牧兽医学报,2017,48(3):393-402,10.基金项目
国家科技支撑计划(2015BAD12B02) （2015BAD12B02）
国家自然科学基金(31402223 （）
31602088) （）
兰州市城关区科技计划(2012-2-1) （2012-2-1）
科研院所基金(1610312016027) （1610312016027）
