中国医疗设备2017，Vol.32Issue(4)：26-29,4.DOI:10.3969/j.issn.1674-1633.2017.04.008
量子点复合微球的活体荧光和化学发光双模式成像
Quantum Dots Composite Microspheres for In Vivo Fluorescence and Chemiluminescence Dual-Mode Imaging
摘要
Abstract
To develop in vivo fluorescence and chemiluminescence dual mode imaging method for materials, quantum dots (QDs) loaded with biodegradable polymer microspheres (BPM) were subcutaneously injected into the back of mice. L-012 was employed to noninvasively monitor the product of reactive oxygen species. The fluorescence intensity and chemiluminescence intensity were observed by Quantitative Fluorescent and Bioluminescent Imaging System IVIS Lumina II from Caliper at different time points. The Results showed that the fluorescence of 30 mg BPM/QD could be detected up to 28 d. Meanwhile, chemiluminescence intensity of the implanted microspheres induced by L-012 decreased with time. On day 28, there was still weak chemiluminescence where the microspheres were implanted.关键词
量子点/复合微球/活体荧光成像/活性氧/化学发光Key words
quantum dots/composite microspheres/in vivo fluorescence imaging/reactive oxygen species/chemiluminescence分类
医药卫生引用本文复制引用
叶一,王国武,王莉萍,和田智之,王瑾晔..量子点复合微球的活体荧光和化学发光双模式成像[J].中国医疗设备,2017,32(4):26-29,4.基金项目
国家自然科学基金(30470477,30870635) （30470477,30870635）
科技部国家国际科技合作计划项目(2015DFG32730) （2015DFG32730）
上海市科学技术委员会国际合作重点项目(15540723900). （15540723900）
