医疗卫生装备2017，Vol.38Issue(3)：1-5,5.DOI:10.7687/J.ISSN1003-8868.2017.03.001
一种应力性骨折动物模型构建新装置的研制
Development of new loading device for establishment of stress fracture animal models
摘要
Abstract
Objective To develop a novel stress fracture animal model system based on dynamic cyclic mechanical loading.Methods Ulnae and tibiae of rats were respectively fixed using differently shaped fixtures (including a fixed holder and a movable holder).The axial mechanical loading was applied via a linear actuator based on LabVIEW control program.During the loading process,a load cell and a laser displacement transducer were used to detect the force and displacement changes in the limbs,respectively.The two signals were sampled at real time by PC-based LabVIEW data acquisition program.A compressive loading test (peak force of 50 N) was conducted to examine the consistency and reliability of cyclic loads after completing the loading system.The loading system and an ElectroForce 3220 mechanical testing machine were respectively used to measure and compare the Young's modulus of a standard ultra-high molecular weight polyethylene (UHMWPE)cylinder to calibrate the loading system.Results The compressive loading test (peak force of 50 N) demonstrated that the mechanical loading system was able to apply consistent loads with controllable intensity and time.The calibration experiment indicated the accuracy of the loading system.Conclusion The novel mechanical loading device has characteristics of precision,scientificity and reliability,and it is approaching the real development situation of stress fracture,which may provide a reliable experimental base for exploring the precautionary measures of stress fracture.关键词
应力性骨折/动物模型构建/应力加载/骨骼生物力学/线性促动器Key words
stress fracture/establishment of animal model/compressive loading/bone biomechanics/linear actuator分类
医药卫生引用本文复制引用
张旭慧,罗二平,景达,王盼,颜泽栋,刘曦雨,单帅,翟明明,谢康宁,刘娟..一种应力性骨折动物模型构建新装置的研制[J].医疗卫生装备,2017,38(3):1-5,5.基金项目
国家自然科学基金面上项目(81471806) （81471806）
陕西省自然科学基金(2014JQ4139) （2014JQ4139）
