中国当代儿科杂志2017，Vol.19Issue(4)：398-401,4.DOI:10.7499/j.issn.1008-8830.2017.04.007
血清高迁移率族蛋白B1与新生儿呼吸窘迫综合征的相关性研究
Association between high-mobility group box 1 and neonatal respiratory distress syndrome
王文秀 1陈波 1章伟 1张惠荣1
作者信息
- 1. 石河子大学医学院第一附属医院儿科,新疆 石河子 832000
- 折叠
摘要
Abstract
Objective To study the association between serum level of high-mobility group box 1(HMGB1) and neonatal respiratory distress syndrome (NRDS). Methods A total of 35 infants with NRDS and 35 normal neonates (control group) were enrolled. Peripheral venous blood samples were collected with 12-24 hours after birth. ELISA was used to measure the serum level of HMGB1. Results The infants with mild and severe NRDS had a significantly higher serum level of HMGB1 than the control group (P<0.05). The infants with severe NRDS had a significantly higher serum level of HMGB1 than those with mild NRDS (P<0.05). The infants with NRDS who died had a significantly higher serum level of HMGB1 than those who survived (P<0.05). The receiver operating characteristic (ROC) curve showed that the optimal cut-off value for serum level of HMGB1 to predict NRDS was 625.3 pg/mL with an area under the ROC curve (AUC) of 0.846 (95%CI: 0.755-0.936), and the optimal cut-off value for serum level of HMGB1 to predict the death of infants with NRDS was 772.2 pg/mL with an AUC of 0.916 (95%CI: 0.813-1.000). Conclusions Infants with NRDS have a significant increase in the serum level of HMGB1, and the serum level of HMGB1 can well predict the development and prognosis of NRDS.关键词
呼吸窘迫综合征/高迁移率族蛋白B1/诊断/预后/新生儿Key words
Respiratory distress syndrome/High-mobility group box 1/Diagnosis/Prognosis/Neonate引用本文复制引用
王文秀,陈波,章伟,张惠荣..血清高迁移率族蛋白B1与新生儿呼吸窘迫综合征的相关性研究[J].中国当代儿科杂志,2017,19(4):398-401,4.
