中国动脉硬化杂志2017，Vol.25Issue(3)：224-229,6.
高血脂通过低密度脂蛋白胆固醇受体与p38-MAPK信号通路加重脑缺血
Low density lipoprotein receptor and p38-MAPK signaling pathway in mechanism of cerebral ischemia with high blood lipid
摘要
Abstract
Aim The relationship between p38 mitogen activated protein (p38-MAPK) and low density lipoprotein receptor (LDLR) in high blood lipid and cerebral ischemia is not clear.This study aims to explore the problem.Methods SD rats were divided into normal diet group and high fat diet group feeding for 30 days and the middle cerebral artery occlusion (MCAO)was induced by the middle cerebral artery occlusion.Serum lipid levels were determined.Neural activity score,infarct weight of ischemic brain tissue and apoptosis,p-p38 expression,LDLR and pp38 double staining index were determined to observe the effect of high fat diet on the extent of cerebral ischemia.Results Serum TG,TC,LDL of fat diet group were significantly higher than normal diet group.Neural activity score,infarct weight of ischemic brain tissue and apoptosis,p-p38 expression,LDLR and p-p38 expression were significantly higher than normal diet group.Conclusion p-p38 was located in the CA1 region.This experiment from LDLR receptor pathway and p38 MAPK signal pathway (and macrophage inflammatory link) of two link annotation high blood lipids as risk factors of cerebral ischemiaessence,provides pharmacology reference for the treatment of hyperlipidemia induced by cerebral ischemia.关键词
局灶性脑缺血/低密度脂蛋白胆固醇受体/p38-丝裂原激活蛋白激酶信号通路Key words
MCAO/LDLR/p38-MAPK分类
医药卫生引用本文复制引用
王蕾,郝迪,王宏,王梓,刘伟伟,聂卫,刘洪斌..高血脂通过低密度脂蛋白胆固醇受体与p38-MAPK信号通路加重脑缺血[J].中国动脉硬化杂志,2017,25(3):224-229,6.基金项目
国家自然科学基金青年基金项目(81202801) （81202801）
天津市卫生和计划生育委员会科技基金项目(2015KR04) （2015KR04）
