中国动脉硬化杂志2017，Vol.25Issue(3)：264-268,5.
替格瑞洛对急性ST段抬高型心肌梗死患者血清hs-CRP和ESM-1水平的影响及短期预后观察
The effect of ticagrelor on serum hs-CRP and ESM-1 and short-term prognosis of patients with acute ST-segment elevation myocardial infarction
摘要
Abstract
Aim To observe the changes of serum high sensitivity C-reactive protein (hs-CRP) and endothelial cell-specific molecule-1 (ESM-1) levels and short-term prognosis of ticagrelor in treatment of patients with acute ST-segment elevation myocardial infarction (STEMI).Methods A total of 107 patients with acute STEMI were selected,all of whom were treated in department of cardiology in our hospital for new onset of symptoms and received emergency PCI successfully.The patients were divided into two groups according to the application of ticagrelor in dual antiplatelet therapy (DAPT):ticagrelor group (n =54) and clopidogrel group (n =53).Two groups of patients were observed for changes of hs-CRP and ESM-1 immediately after admission as well as 24 h,4 d and 7 d after medication,their correlation,and influences of ticagrelor on short-term prognosis of patients with acute STEMI.Results Hs-CRP and ESM-1 of the two groups of patients were obviously elevated at 24 h after medication,and there were statistical differences (P＜0.05),and hs-CRP and ESM-1 of the two groups of patients were decreasing at 4 d and 7 d,with statistically significant differences (P＜0.05);ESM-1 was increased with the increase of hs-CRP,showing a positive correlation between ESM-1 and hs-CRP (r=0.535,P＜0.001),there were no statistical differences in comparison between the two groups in incidences of ischemic end event,hemorrhagic event and total adverse events (P＞0.05).Conclusions Ticagrelor can more quickly reduce the cell inflammation and stabilize endothelium in treatment of STEMIpatients,so as to improve the stability of atherosclerotic plaque,reduce the formation of thrombus and ischemic end events,but it does not increase the risk of bleeding,which is worth of clinical application.关键词
替格瑞洛/急性ST段抬高型心肌梗死/经皮冠状动脉介入治疗/内皮细胞特异性分子1/高敏C反应蛋白Key words
Ticagrelor/Acute ST-segment elevation myocardial infarction/Percutaneous coronary intervention/Endothelial cell-specific molecule-1/High sensitivity C-reactive protein分类
医药卫生引用本文复制引用
魏鹏,杨向军,付强,路雯,凌琳,宗斌,张文俊,邱崇荣,白洁..替格瑞洛对急性ST段抬高型心肌梗死患者血清hs-CRP和ESM-1水平的影响及短期预后观察[J].中国动脉硬化杂志,2017,25(3):264-268,5.基金项目
江苏省青年医学人才项目资助(QNRC2016382) （QNRC2016382）
徐州市社会发展项目资助(KC16SH028) （KC16SH028）
