中国动脉硬化杂志2017，Vol.25Issue(3)：288-292,5.
一般人群中尿蛋白水平对主要不良心脑血管事件及全因死亡的影响
Effects of urinary protein level on major adverse cardiac and cerebrovascular event and all-cause death in general population cohorts
王剑利 1李俊娟 1周靖 1刘艳 1吴寿岭2
作者信息
- 1. 开滦集团开滦总医院,河北省唐山市063000
- 2. 开滦集团开滦职工健康保障中心,河北省唐山市063000
- 折叠
摘要
Abstract
Aim To study the effect of urinary protein level on major adverse cardiac and cerebrovascular event (MACCE) and all-cause death in general population cohorts.Methods Prospective cohort study method was used in this study.Health examination data integrity 87292 cases were selected as the research subjects from July 2006 to October 2007 in Kailuan Group.The average age of research subjects was 51.12± 12.29 years old.Urine dipstick test was used to detect morning urine.According to the level of urinary protein,population were classified into three groups:urine protein negative group (-),micro-urine protein group (±/+),and macro-urine protein group (≥ 2 +).COX proportional hazards model was used to analyze the relationship between urinary protein and MACCE,all-cause death.Results The average follow-up was 6.90±0.72 years.During follow-up there were 3091 cases of MACCE,the cumulative incidence was 5.25/1000 person-year,and there were 4087 cases of all-cause death,the cumulative incidence was 6.84/1000 personyear.The cumulative incidences of MACCE in the three groups were respectively 4.84/1000 person-year,7.34/1000 person-year,12.06/1000 person-year.The cumulative incidences of all-cause death in the three groups were respectively 6.10/1000 person-year,10.28/1000 person-year,19.30/1000 person-year.The differences among the three groups were statistically significant (P＜0.01).After adjusting for other traditional risk factors,compared with urine protein negative group,RR values of MACCE in micro-urine protein group and macro-urine protein group were respectively 1.24 (95％CI 1.10-1.40) and 1.58 (95％CI 1.38-1.81),and RR values of all-cause death were respectively 1.41 (95％CI 1.27-1.56)and 2.15 (95％CI 1.93-2.39).Conclusion Urine displayed urinary protein is an independent risk factor for MACCE and all-cause death in the general population.关键词
尿蛋白/主要不良心脑血管事件/全因死亡Key words
Urinary protein/Major adverse cardiac and cerebrovascular event/All-cause death分类
医药卫生引用本文复制引用
王剑利,李俊娟,周靖,刘艳,吴寿岭..一般人群中尿蛋白水平对主要不良心脑血管事件及全因死亡的影响[J].中国动脉硬化杂志,2017,25(3):288-292,5.
