中国感染控制杂志2017，Vol.16Issue(1)：32-35,57,5.DOI:10.3969/j.issn.1671-9638.2017.01.007
评价泊沙康唑预防血液系统疾病患者粒细胞缺乏期侵袭性真菌病的效果
Efficacy of posaconazole in preventing invasive fungal disease in hematologic patients with neutropenia
徐宵寒 1张路 1段明辉1
作者信息
- 1. 中国医学科学院北京协和医院,北京100730
- 折叠
摘要
Abstract
Objective To evaluate the prophylactic efficacy and safety of posaconazole against invasive fungal disease(IFD)in hematologic patients with neutropenia.Methods Medical records of 18 hematologic patients with neutropenia received posaconazole for preventing IFD in a Beijing hospital between 2014 and 2015,the efficacy and safety was evaluated.Results There was no clinical diagnosis or confirmed diagnosis of IFD among 18 patients during posaconazole prophylaxis period,none of patients stopped posaconazole due to severe adverse reaction.Two patients with acute myeloid leukemia(AML) died of pulmonary infection,1 of whom isolated Stenotrophomonas maltophilia from sputum culture on the 12th day of posaconazole prophylaxis,the other isolated Escherichia coli from sputum culture on the 14th day of posaconazole prophylaxis.Other patients all adherence to posaconazole prophylaxis until granulocyte count recovered,patients were followed up until 100 days medication,no death occurred.The lowest peripheral neutrophil count was(0.00-0.27) x 109/L during posaconazole prophylaxis period,with the median of 0.02 x 109/L;the duration of posaconazole prophylaxis was 8-27days,with the median of 16 days;among patients without IFD breakthrough or received systemic use of other antifungal agents,there were 2 (11.1％) all-cause death within 100 days;there were no adverse reaction,such as liver function abnormalities≥grade 2 and kidney function abnormalities≥grade 2,as well as QTc prolongation.Conclusion Posaconazole is effective for preventing IFD in hematologic patients with neutropenia,adverse reaction is rare.关键词
泊沙康唑/急性白血病/再生障碍性贫血/粒细胞缺乏/侵袭性真菌病/预防用药Key words
posaconazole/acute leukemia/aplastic anemia/neutropenia/invasive fungal disease/antimicrobial prophylaxis分类
医药卫生引用本文复制引用
徐宵寒,张路,段明辉..评价泊沙康唑预防血液系统疾病患者粒细胞缺乏期侵袭性真菌病的效果[J].中国感染控制杂志,2017,16(1):32-35,57,5.
