局解手术学杂志2017，Vol.26Issue(2)：82-85,4.DOI:10.11659/jjssx.08E016014
头颈部鳞癌中FOXP3基因相关的竞争性内源性RNA网络分析
FOXP3-related ceRNA network analysis in head and neck squamous cell carcinoma
摘要
Abstract
Objective To explore the FOXP3-related mechanism underlying head and neck squamous cell carcinoma.Methods We used cbioportal to identify the co-expressed genes of FOXP3 in 279 samples from head and neck squamous cell carcinoma in TCGA database.We used String database to establish the co-expression network of FOXP3.The function of co-expression network was identified through DAVID database.We used miRTarBase and StarBase database to screen the microRNA,lncRNA and circRNA that regulate FOXP3.Finally,Cytoscape software was used to establish FOXP3-related ceRNA network.Results We found 950 FOXP3 related co-expressed gene.(Spearman score over 0.5) These genes were enriched in immune response including T cell,leukocyte and lymphocyte activation.CeRNA network revealed that 2 microRNAs (i.e.,miR-31-5p and miR-210-3p),42 lncRNAs (e.g.,XIST,TUG1,JRK and LINC00473) and 31 circRNAs (e.g.,ZNF223 _hsa_ circ_ 000898 and ISY1 _hsa _circ _001090) could regulate FOXP3.Conclusion We established FOXP3-related ceRNA network and identified 42 lncRNAs and 31 circRNAs that regulate FOXP3.The data generated from this study could provide a new cut point in research and treatment of head and neck squamous cell carcinoma.关键词
喉鳞状细胞癌/FOXP3/长链非编码RNA/环状非编码RNA/竞争性内源性RNA/短链非编码RNA/靶向治疗Key words
laryngeal squamous cell carcinoma/FOXP3/lncRNA/circRNA/ceRNA/microRNA/targeted therapy分类
医药卫生引用本文复制引用
孙娟,王薇,胡文良,孙学威,李玲香,崔晓波..头颈部鳞癌中FOXP3基因相关的竞争性内源性RNA网络分析[J].局解手术学杂志,2017,26(2):82-85,4.基金项目
内蒙古自治区自然科学基金(2014MS0856) （2014MS0856）
内蒙古医科大学科技百万工程项目(KJbw2013014) （KJbw2013014）
