局解手术学杂志2017，Vol.26Issue(2)：86-89,4.DOI:10.11659/jjssx.08E016005
替来他明和唑拉西泮复合麻醉对比格犬生理及血气指标的影响
Effect on physiological and blood gas indicators of beagles by combined anesthesia with tiletamine and zolazepam
摘要
Abstract
Objective To study the physiological indicators and arterial blood gas values,and create a reliable data for researchers using beagle dogs.Methods Beagle were sampled before and after Zoletil anesthesia (10 mg/kg) via intramuscular injection.Then aterial blood gas was detected by blood gas analyzer.Then the physiological indicators,including heart rate,blood pressure and body temperature were measured via large animal ECG.Results For blood gas values,the pH value decreased significantly (P ＜ 0.01).pCO2 increased significantly and pO2 decreased significantly,the differences were significantly (P ＜ 0.05).In contrast,levels of Lac and HCO3-remained unaltered,indicating a typical respiratory acidosis.For physiological indicators,blood pressure increased slightly,but not significant.The heart rate increased significantly (P ＜ 0.01) and body temperature decreased significantly (P ＜ 0.01).There was no difference between sexes.Conclusion Zoletil anesthesia causes respiratory arrest and respiratory congestion,which further induced respiratory acidosis.Meanwhile,anesthesia also results in elevated heart rhythm and lower body temperature.These data indicate that warming and airway clear are necessary during anesthesia in Beagles.Moreover,it should be considered about the effects of anaesthetics when comparing differents in animals before and after treatment.关键词
比格犬/替来他明/唑拉西泮/复合麻醉/生理指标/血气Key words
beagle/tiletamine/zolazepam/combined anesthesia/physiological indicators/blood gas分类
医药卫生引用本文复制引用
鲁永玲,范仕郡,陈倩,郑江..替来他明和唑拉西泮复合麻醉对比格犬生理及血气指标的影响[J].局解手术学杂志,2017,26(2):86-89,4.基金项目
国家自然科学基金(81372089) （81372089）
