局解手术学杂志2017，Vol.26Issue(2)：94-97,4.DOI:10.11659/jjssx.08E016067
普罗布考对动脉硬化闭塞症兔体内炎症反应的影响
Effect of probucol on inflammatory response in rabbits with arteriosclerosis obliterans
高真生 1刘国利 1李博 1杨春宁 1李岩1
作者信息
- 1. 沈阳医学院附属第二医院血管外科,辽宁沈阳110023
- 折叠
摘要
Abstract
Objective To explore the effect of probucol on the inflammatory response in rabbits with arteriosclerosis obliterans.Methods SPF male new zealand white rabbits were subjected to incomplete right femoral artery ligation model of arteriosclerosis obliterans.The model rabbits were divided into experimental group and control group.The rabbits in experimental group were treated by probucol.After treatment for 4 weeks,HE staining was used to evaluate the injury severity of right femoral artery in rabbits;ELISA was used to measure the levels of IL-1,IL-6,TNF-α and CRP;Realtime PCR was used to detect the expressions of IL-1,TNF-α in right femoral artery;Western blot was used to measured the nucleus accumulations of NF-κB,and the phosphorylation of IκB.Results Compared with control group,the degree of pathological injury of right femoral artery was significantly atteunated,the levels of IL-1 、IL-6 、TNF-α and CRP in plasma,the mRNA expressions of IL-1 、TNF-α and the nucleus accumulations of NF-κB,and the phosphorylation of IκB in right femoral artery decreased significantly.Conclusion Probucol attenuates the inflammatory response in rabbits with arteriosclerosis obliterans significantly.关键词
普罗布考/动脉硬化闭塞症/动脉粥样硬化/炎症反应/周围血管疾病Key words
probucol/arteriosclerosis obliterans/atherosclerosis/inflammatory response/peripheral vascular disease分类
医药卫生引用本文复制引用
高真生,刘国利,李博,杨春宁,李岩..普罗布考对动脉硬化闭塞症兔体内炎症反应的影响[J].局解手术学杂志,2017,26(2):94-97,4.
