局解手术学杂志2017，Vol.26Issue(2)：136-139,4.DOI:10.11659/jjssx.07E016059
丙泊酚静脉麻醉对原发性肝癌围手术期T辅助细胞的影响
Influence of propofol intravenous anesthesia on T helper cells of patients with primary liver cancer in perioperative period
黎敏 1金丹 1陈树发 1贯璇1
作者信息
- 1. 香港大学深圳医院麻醉科,广东深圳518000
- 折叠
摘要
Abstract
Objective To study the effect of propofol intravenous anesthesia on T helper cells of patients with primary liver cancer during perioperative period.Methods A total of 86 patients with primary liver cancer in our hospital from November 2014 to October 2015 were selected,who were divided into observation group and control group according to the method of random numbers,43 cases in each group.The observation group were taken propofol intravenous anesthesia,and the control group were treated with sevoflurane inhalation anesthesia.The Th1 cells percentage,Th2 cells percentage and the ratio changes of the Th1/Th2 cells of two groups before anesthesia and postoperative 1 day were compared.The plasma cortisol levels of two groups before anesthesia,after anesthesia,intraoperative and 1 day after operation were observed.Results The percentage of Th2 cells in observation group and control group 1 day after surgery had no significant difference (P ＞ 0.05).The percentage of Th1 cells and Th1/Th2 cells ratio of the observation group were higher than those of the control group [(16.32 ± 1.76) ％ vs.(14.16 ± 1.03),(8.48 ± 0.92) vs.(7.11 ± 0.72)],the differences were significant (P ＜ 0.05).The plasma cortisol levels of observation group during operation and 1 day after operation were lower than those of the control group[(12.34 ± 1.02) μg/dL vs.(16.13 ± 1.26) μg/dL,(12.01 ± 0.94) μg/dL vs.(15.25 ± 1.08) μg/dL],the differences were significant(P ＜ 0.05).Conclusion The propofol intravenous anesthesia can encourage more Th to differentiate into Th1 cells,which plays a protective role in the patient's immune function.关键词
七氟醚/丙泊酚/麻醉/肝癌/T辅助细胞Key words
sevoflurane/propofol/anesthesia/liver cancer/T helper cells分类
医药卫生引用本文复制引用
黎敏,金丹,陈树发,贯璇..丙泊酚静脉麻醉对原发性肝癌围手术期T辅助细胞的影响[J].局解手术学杂志,2017,26(2):136-139,4.
