中国临床药理学杂志2017，Vol.33Issue(5)：408-410,3.DOI:10.13699/j.cnki.1001-6821.2017.05.007
丙泊酚注射剂治疗活动过多型谵妄的临床研究
Clinical trial of propofol injection in the treatment of hyperactive delirium
摘要
Abstract
Objective To observe the clinical efficacy and safety of propofol injection in the treatment of hyperactive delirium.Methods One hundred patients with hyperactive delirium were randomly divided into control group (n =48 cases) and treatment group (n =52 cases).Control group was given loading dose of 1 μg · kg-1 dexmedetomidine for 10 min with intravenous push,then continuous intravenous infusion for 10 min with 0.52-0.70 μg · kg-1 · h-1.Treatment group was given 0.5 mg · kg-1propofol with intravenous push,then continuous intravenous infusion for 5 min with 0.5-1.0 μg · kg-1 · h-1 Two groups were treated for 2 h.The clinical efficacy and adverse drug reactions were compared between two groups.Results After treatment,the main indexes in treatment and control groups were compared between two groups:the intensive care delirium screening checklist were (1.26 ± 0.57),(2.53 ± 0.76) points;total delirium duration were (20.15 ±4.67),(26.46 ± 5.12)h;duration of restless delirium were (8.32 ± 2.48),(12.32 ± 4.14) h;delirium recurrence rates were 3.85％,18.75％;duration of mechanical ventilation were (50.65±8.84),(60.67 ± 7.98) h;extubation time were (52.76 ± 7.98),(62.38 ± 8.95) h;intensive care unit time were (114.59 ± 10.76),(123.43 ± 9.87) h,with significant difference (P ＜ 0.05).The adverse drug reactions in two groups were based on hypotension,bradycardia and acute dystonia.The incidences of adverse drug reactions in treatment and control groups were 21.15％ and 27.08％ without significant difference (P ＜ 0.05).Conclusion Propofol injection has a definitive clinical efficacy in the treatment of hyperactive delirium,without increasing the incidence of adverse drug reactions.关键词
丙泊酚注射剂/活动过多型谵妄/安全性Key words
propofol injection/hyperactive delirium/safety分类
医药卫生引用本文复制引用
吴颖,刘淑红,刘亚晶,亢宏山,彭丽..丙泊酚注射剂治疗活动过多型谵妄的临床研究[J].中国临床药理学杂志,2017,33(5):408-410,3.基金项目
衡水市科学研究与发展计划(医药卫生)基金资助项目(14019A) （医药卫生）
