中国临床药理学杂志2017，Vol.33Issue(6)：490-492,3.DOI:10.13699/j.cnki.1001-6821.2017.06.003
注射用鼠神经生长因子治疗老年痴呆患者的临床研究
Clinical trial of mouse nerve growth factor in the treatment with senile dementia
摘要
Abstract
Objective To evaluate the clinical effect and serum cytokines levels of mouse nerve growth factor during the treatment of senile dementia.Methods A total of 90 senile dementia patients were randomly divided into treatment group and control group,each group 45 cases.Control group was given conventional treatment.Treatment group was intravenous drip mouse nerve growth factor 20 μg,qd on the basis of control group.All patients were treated for 6 weeks.The cognitive function,dementia degree,daily life ability before treatment and 6,12 weeks after treatment in two groups were observed.The levels of serum interleukin-1β (IL-1β),interleukin-6 (IL-6),C-reactive protein(CRP),tumor necrosis factor-α (TNF-α) in two group were observed.Results The mental state examination(MMSE),activity of daily life (ADL),clinical dementia rating (CDR) in two group after 12 weeks treatment had significant difference (P ＜ 0.05).The IL-1 β in treatment group after 6,12 weeks treatment were (20.88 ± 5.83),(18.35 ±3.96) ng · L-1,and were (21.12 ±6.12),(20.76 ±4.83) ng· L-1 in control group.The IL-6 in treatment group after 6,12 weeks treatment were (24.33 ± 8.56),(18.85 ±5.83) ng · L-1,and were (24.84 ±9.13),(21.64 ± 6.68) ng · L-1 in control group.The CRP in treatment group after 6,12 weeks treatment were (6.43 ± 1.65),(5.27 ± 0.63)ng · L-1,and were (6.73 ± 1.73),(6.17 ± 0.95) ng · L-1 in control group.The TNF-α in treatment group after 6,12 weeks treatment were (40.52 ±8.33),(36.34 ±5.92) ng · L-1,and were (40.85 ±9.15),(39.46 ±6.44) ng · L-1 in control group.The IL-1β,IL-6,CRP,TNF-α in two group after 12 weeks treatment had significant difference (P ＜0.05).There was 1 case of mild headache in control group,the incidence of adverse drug reactions was 0.02％ (1/45 cases).There was no adverse drug reaction occurred in treatment group.Conclusion The clinical effect of nerve growth factor in the treatment of senile dementia is significant,and can improve the living ability,relieve the symptoms of dementia,reduce the level of serum cytokines.关键词
注射用鼠神经生长因子/老年痴呆/细胞因子/预后Key words
mouse nerve growth factor/senile dementia/cytokine/prognosis分类
医药卫生引用本文复制引用
黄年平,付棟,邓志洪..注射用鼠神经生长因子治疗老年痴呆患者的临床研究[J].中国临床药理学杂志,2017,33(6):490-492,3.基金项目
湖北省卫生厅科研一般基金资助项目(2013～2014年JX6B81) （2013～2014年JX6B81）
