中国临床药理学杂志2017，Vol.33Issue(6)：493-495,3.DOI:10.13699/j.cnki.1001-6821.2017.06.004
中国汉族健康人群CYP24A1的基因多态性研究
Study on genetic polymorphisms of cytochrome P450 24A1 in healthy Han Chinese population
摘要
Abstract
Objective To detect the polymorphisms and haplotype of 25 -hydroxyvitamin-D3-24-hydroxylase (CYP24A1) in Chinese healthy Han population.Methods Two hundred and three Chinese Han healthy volunteers were entrolled in this study.Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF -MS) was used to identify the polymorphisms of CYP24A1.The haplotype frequencies were analyzed by Phase 2.1.Results The frequency distribution of CYP24A1 rs1570669,rs34043203,rs3787557,rs6068816 were 36.0％,16.3％,24.4％,31.5％.The frequency distribution of GCTT,GCTC,GCCC,ATTC in CYP24A1 haplotype were 27.7％,17.2％,14.3％,12.5％.Conclusion The frequencies of these variants were high in Chinese healthy Han population.The frequency of GCTT haplotype was high as well.关键词
细胞色素P450 24A1/基因多态性/分布频率Key words
cytochrome P450 24A1/genetic polymorphisms/distribution frequency分类
医药卫生引用本文复制引用
林晓贞,张斌,贺宝霞,赵秀莉,张文周,李红霞,田锋奇,杜娟,杨微,于卫江..中国汉族健康人群CYP24A1的基因多态性研究[J].中国临床药理学杂志,2017,33(6):493-495,3.基金项目
国家自然科学基金青年基金资助项目(81302796) （81302796）
河南省科技计划攻关基金资助项目(162102310157) （162102310157）
