中国临床药理学杂志2017，Vol.33Issue(6)：496-498,3.DOI:10.13699/j.cnki.1001-6821.2017.06.005
阿仑膦酸钠片联合阿法骨化醇胶囊治疗围绝经期骨质疏松的临床研究
Clinical trial of alendronate tablets combined with alfacalcidolon capsules in the treatment of perimenopausal women with osteoporosis
摘要
Abstract
Objective To observe the clinical efficacy and safety of alendronate tablets combined with alfacalcidolon capsules in the treatment of perimenopausal women with osteoporosis.Methods A total of 56 perimenopausal women with osteoporosis were randomly divided into control group and treatment group with 28 cases per group.Control group was treated with alfacalcidolon capsule 0.25 μg qd oral.Treatment group was given alendronate sodium tablet 70 mg qd oral,on the basis of control group.The chnical efficacy,serum aquaporin 1 (AQP1),matrix metalloproteinase 2 (MMP-2),bone alkaline phosphatase (BALP),type Ⅰ collagen C end peptide (CTX-Ⅰ)and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in treatment and control groups were 92.86％ (26/28 cases) and 71.43％ (20/28 cases) with significant difference (P ＜0.05).After treatment,the main indexes in treatment and control groups were compared:AQP1 were (23.53 ± 3.02),(30.65 ± 4.31) μg · L-1;MMP-2 were (60.37 ± 8.35),(66.45 ± 8.47) μg · L-1;BALP were (20.04±2.57),(24.38 ±3.32) pg · L-1;CTX-Ⅰ were (0.75 ±0.06),(0.83 ±0.09)ng · L-1,the differences were statistically significant (P ＜ 0.05).The adverse drug reactions in treatment group were based on diarrhea and nausea,which in control group was based on diarrhea and nausea.The incidence of adverse drug reactions in two groups were 7.14％ without significant difference (P ＞ 0.05).Conclusion Alendronate tablets combined with alfacalcidolon capsules have a definitive clinical efficacy in the treatment of perimenopausal women with osteoporosis,which can significantly reduce the serum levels of AQP1,MMP-2,BALP and CTX-Ⅰ,without increasing the incidence of adverse drug reactions.关键词
阿仑膦酸钠片/阿法骨化醇胶囊/围绝经期骨质疏松/安全性Key words
alendronate sodium tablet/alfacalcidolon capsule/perimenopausal osteoporosis/safety分类
医药卫生引用本文复制引用
邱奕雁,陈鹏飞,陈扬,周文钰,夏晓龙,杨欣建..阿仑膦酸钠片联合阿法骨化醇胶囊治疗围绝经期骨质疏松的临床研究[J].中国临床药理学杂志,2017,33(6):496-498,3.基金项目
广东省中医药局基金资助项目(20141257) （20141257）
