摘要
Abstract
Objective To observe the clinical efficacy and safety of compound mifepristone tablets combined with misoprostol tablets in termination pregnancy from 10 to 16 weeks and treatment of missed abortion.Methods A total of 419 patients with pregnancy from 10 to 16 weeks (n=269 cases) and missed abortion (n =150 cases) were randomly divided into group A (termination pregnancy with mifepristone,n =95 cases),group B (termination pregnancy with compound mifepristone,n =174 cases),group C (missed abortion with mifepristone,n =53 cases) and group D (missed abortion with compound mifepristone,n =97 cases).Group A and group C were given mifepristone 50 mg bid oral,12 h after the third administration,misoprostol 0.6 mg in 0.9％ NaCl humidified was placed in the vagina.Group B and group D were given compound mifepristone 35 mg qd oral,12 h after the second administration,misoprostol 0.6 mg in 0.9％ NaCl humidified was placed in the vagina.The success rate of drug abortion and adverse drug reactions were compared between four groups.Results After treatment,the success rates of drug abortion and adverse drug in groups A,B,C,D were 92.63％ (88/95 cases),82.76％ (144/174 cases),77.36％ (41/53 cases),76.29％ (74/97 cases),the difference was significant between group A and group B (P ＜0.05),but which was not significant between group C and group D (P ＞ 0.05).The adverse drug reactions were based on nausea and vomiting,dizziness,fatigue,rash,palms itching,fever and diarrhea in four groups.The incidences of adverse drug reactions in groups A,B,C,D were 51.58％,53.45％,54.72％,55.67％,without significant difference (P ＞ 0.05).Conclusion Clinical efficacy of compound mifepristone tablets combined with misoprostol tablets in the treatment of termination pregnancy from 10 to 16 weeks is less than mifepristone combined with misoprostol tablets,but they have the same clinical efficacy in the treatment of missed abortion,without increasing the incidence of adverse drug reactions.关键词
复方米非司酮片/米非司酮片/米索前列醇片/终止妊娠/稽留流产Key words
compound mifepristone/mifepristone/misoprostol/pregnancy termination/missed abortion分类
医药卫生
